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肝癌是最常见的原发性肝肿瘤，其发生与乙肝病毒或丙肝病毒感染因素有关，但确切的发病机制尚不明确。目前临床上对于肝癌主要采用手术、局部治疗和肝移植等综合疗法，但预后差，肝癌患者的五年生存率仍小于8%。很多研究表明环加氧酶-2 (COX-2)在肝癌发生中起重要作用，COX-2特异性抑制剂能够有效抑制肝癌的增殖和侵袭迁移。这些发现为肝癌的防治提供了新的思路。本文就COX-2与肝癌的关系做一概述。
观察IL-10在H.pylori相关性胃炎组织中的表达及与COX-2、iNOS的相关性。方法:选取74例H.pylori相关性胃炎患者，均行H.pylori检测确定H.pylori感染情况，行病理组织学检测明确病理分型、胃黏膜炎症程度，行免疫组化检测胃黏膜中IL-10、COX-2、iNOS表达。分析H.pylori感染情况、病理诊断与组织分型结果，明确慢性胃炎患者H.pylori感染与病理炎症程度...
中长期电力负荷预测是电力部门制定电力系统发展规划和稳定运行的重要前提.针对影响中长期电力负荷预测精度的多个因素，本文利用逐步回归方法，从众多影响负荷预测精度的关联因子中，对关键的影响因子进行辨识，并提出基于Box-Cox变换分位数回归和核密度估计相结合的概率密度预测方法，得出不同分位点下未来连续几年的概率密度预测结果，实现了对未来年用电量准确波动区间的预测.以安徽省的历史用电量和社会经济数据为例，...
黏土岩具有低渗性和自我裂缝修复能力等优点，被用于高放废物地质处置的候选基岩。出于高放废物处置库的长期性及高安全性要求，研究黏土岩的蠕变破坏特征显得极其重要。通过一系列黏土岩的单级三轴压缩蠕变试验，获得Callovo-Oxfordian(COx)黏土岩较为精确的蠕变速率阈值范围。试验结果表明，发生蠕变破坏的蠕变速率阈值与黏土岩的湿度及所处围压等因素有关。总体上，当轴向蠕变速率低于2.5 με/h，该...
Full likelihood inferences in the Cox model:an empirical likelihood approach
Right censored data Empirical likelihood Maximum likelihood estimator Partial likelihood Profile likelihood
2015/12/11
For the regression parameter β0 in the Cox model, there have been several estimators constructed based on various types of approximated likelihood, but none of them has demonstrated small-sample advan...
Estimation and goodness-of-fit for the Cox model with various types of censored data
Bivariate right censored data Bivariate data under univariate right censoring Bootstrap Doubly censored data Empirical likelihood Goodness-of-fit Partly interval-censored data
2015/12/11
The currently existing estimation methods and goodness-of-fit tests for the Cox model mainly deal with right censored data, but they do not have direct extension to other complicated types of censored...
Regularization Paths for Cox’s Proportional Hazards Model via Coordinate Descent
survival Cox model lasso elastic net
2015/8/21
We introduce a pathwise algorithm for the Cox proportional hazards model, regularized by convex combinations of `1 and `2 penalties (elastic net). Our algorithm fits via cyclical coordinate descent, a...
一类变保费双Cox风险模型的鞅分析
Cox过程 Brown运动 鞅 停时 Lundberg指数
2012/11/12
讨论一类带有投资收益和再保险的变保费双Cox风险模型:U(t)=u+V1(t)=u1+u2+∑〖DD(〗M1(t)〖〗i=1〖DD)〗Xi-∑〖DD(〗M2(t)
〖〗j=1〖DD)〗Zj+u2W(t).假设保单数量过程M1(t)与索赔次数过程M2(t)相依, 使用鞅方法得到了该模型最终破产概率的一个上界表达式e-ru·C(r), 并在特定条件M1(t)...
Exponential and non-exponential upper bounds for the ruin probabilities for the double Cox processes risk models
Probability Double Cox processes Martingale method
2011/11/4
In this paper, we consider a general insurance risk model in which the premium income process and the claim process are based on Cox processes. Exponential upper bounds for ruin probabilities are obta...
一类变保费双Cox风险模型的鞅分析
Cox过程 Brown运动 鞅 停时 Lundberg指数
2012/11/13
讨论一类带有投资收益和再保险的变保费双Cox风险模型:U(t)=u+V1(t)=u1+u2+∑〖DD(〗M1(t)〖〗i=1〖DD)〗Xi-∑〖DD(〗M2(t)〖〗j=1〖DD)〗Zj+u2W(t).假设保单数量过程M1(t)与索赔次数过程M2(t)相依, 使用鞅方法得到了该模型最终破产概率的一个上界表达式e-ru·C(r), 并在特定条件M1(t)=β...
Cox rings and pseudoeffective cones of projectivized toric vector bundles
Cox rings projectivized toric vector bundles
2010/12/13
We study projectivizations of a special class of toric vector bundles that includes cotangent bundles, whose associated Klyachko filtrations are particularly simple.
Cox rings of rational complexity one T-varieties
Cox ring branched coverings torus actions
2010/11/29
Let X be a Mori dream space together with an effective torus action of complexity one. In this note, we construct a polyhedral divisor DCox on a suitable finite covering of P1 which corresponds to the...
Default Risk Modeling Beyond the First-Passage Approximation. I. Extended Black-Cox Model
Default Risk Modeling First-Passage Approximation Black-Cox Model
2010/4/27
We develop a generalization of the Black-Cox structural model of default risk. The extended model captures uncertainty related to firms ability to avoid default even if companys liabilities momentaril...
Allan V. Cox（图）
Allan V. Cox geophysics
2009/4/27
N THE EARLY MORNING of January 27, 1987, Allan Cox died in a bicycle accident, colliding with a large redwood tree after a steep descent on a stretch of mountain road. By this mishap geophysics lost a...