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Polygenic Modeling with Bayesian Sparse Linear Mixed Models
Polygenic Modeling Bayesian Sparse Linear Mixed Models
2012/11/23
Both linear mixed models (LMMs) and sparse regression models are widely used in genetics applications, including, recently, polygenic modeling in genome-wide association studies. These two approaches ...
The statistical mechanics of a polygenic characterunder stabilizing selection, mutation and drift
statistical mechanics polygenic characterunder stabilizing selection mutation drift
2010/11/15
By exploiting an analogy between population genetics and statistical mechanics, we study the evolution of a polygenic trait under stabilizing selection, mutation, and genetic drift. This requires us ...
14种多基因、疑为多基因遗传病的遗传率研究Estimation of heritability of 14 Kinds of Polygenic diseases
多基因遗传病 遗传率
2008/1/20
摘要0.75）; 共转性内斜视、唇裂±腭裂、先天性髋关节关节脱位、多指（趾）症、腹股沟斜疝、银屑病（牛皮癣）及原发性癫痫有遗传倾向（0.60< h2<0.75）； 而共转性外斜视、精索静脉曲张、隐睾症以及先天性心脏病（各型）受遗传因素的作用相对较小（h20.75). The congenital of genetic factors is moderate in con.comitant esot...