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近日，强磁场科学中心刘青松研究员课题组、刘静研究员课题组针对慢性髓细胞性白血病研制出一种新型的具有自主知识产权的BCR-ABL小分子靶向抑制剂CHMFL-074。该研究成果以“Discovery and Characterization of a Novel Potent Type Ⅱ Native and Mutant BCR-ABL Inhibitor (CHMFL-074) for Chro...
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
SOSA – a new model to simulate the concentrations of organic vapours and sulphuric acid inside the ABL – Part 1: Model description and initial evaluation
SOSA organic vapours sulphuric acid the ABL initial evaluation
2011/1/18
Chemistry in the atmospheric boundary layer (ABL) is controlled by complex processes of surface fluxes, flow, turbulent transport, and chemical reactions. We present a new model SOSA (model to simulat...
Contribution of mixing in the ABL to new particle formation based on observations
ABL particle formation
2008/12/19
The connection between new particle formation and micro- and mesoscale meteorology was studied based on measurements at SMEAR II station in Southern Finland. We analyzed turbulent conditions described...
在BCR/ABL基因组上敲入mRNA不稳定元件可逆转K562细胞恶性转化
慢性粒细胞白血病 费城染色体 RNA降解 基因打靶
2007/12/19
摘要 融合基因 BCR/ABL在慢性粒细胞白血病的恶性转化过程中起着主导作用 .针对融合基因的 3′端构建了一个定点基因打靶质粒 ,p F2 .neo.abl(1 - 4) ,将一段可引发核内 RNA降解的元件 ,URE,定点整合到融合基因 poly(A)位点的上游 .打靶质粒经脂质体转染 K562细胞后 ,在 96孔板上进行 40 0 μg/ml G41 8筛选 ,neor克隆进一步在 2 4孔...
间期细胞核中abl和bcr基因的三维空间分布在bcr/abl融合基因形成中的作用
2007/7/25
第9号和22号染色体长臂的易位导致了ph染色体的形成，由此产生的bcr/abl融合基因是慢性粒细胞性白血病(CML)发病的分子遗传学基础[1]。长期追踪调查显示，核爆炸幸存者的bcr和abl基因融合的频率明显增高[2][3]。有研究证实，染色质在间期细胞核内占据着特定的空间，即染色体结构域(chromosomal territory)[4]，而存在于染色体之上的基因位点是非随机分布的。为了研究bc...