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Regularized linear discriminant analysis and its application in microarrays
Regularized linear discriminant analysis microarrays
2015/8/21
In this paper, we introduce a modified version of linear discriminant analysis, called the “shrunken centroids regularized discriminant analysis” (SCRDA). This method generalizes the idea of the “near...
Row and Column Correlations (Are a set of microarrays independent of each other?)
Row Column Correlations
2015/8/20
Having observed an m n matrix X whose rows are possibly correlated, we wish to test the hypothesis that the columns are independent of each other. Our motivation comes from microarray studies,
where...
Microarrays, Empirical Bayes, and the Two-Groups Model
Empirical Bayes the Two-Groups Model
2015/8/20
The classic frequentist theory of hypothesis testing developed by Neyman, Pearson, and Fisher
has a claim to being the Twentieth Century’s most influential piece of applied mathematics. Somethi...