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The role of cell cycle progression and cyclin -dependent kinase 2 in thymocyte negative selection
T cells and thymus cells thymus self antigen cells
2014/12/11
Autoreactive, immature T cells (thymocytes) are deleted from the thymus during development by the process of negative selection. This mechanism occurs when the thymocyte, T cell receptor (TCR) recogni...
Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell
cyclin D1 cell cycle
2006/12/22
18 December 2006，We present evidence that variations in cyclin D1 levels through the cell cycle are essential for continuing proliferation. Cyclin D1 levels must be high during G1 phase for a cell to ...