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近日，华西基础医学与法医学院刘肖珩教授团队在Bone Research发表原创研究论文，证实了基质囊泡来源的AnxA5在骨重塑中的重要作用，阐明了AnxA5通过促进基质囊泡与I型胶原的黏附，诱导骨前体细胞发生自噬和加速矿化预防骨丢失的新机制，为骨质疏松症的防治提供新策略。
Bone mineral density during pregnancy in women participating in a randomized controlled trial of vitamin D supplementation
bone mineral content bone mineral density cholecalciferol pregnancy vitamin D
2018/11/21
Background: Little is known about bone mineral density (BMD) during pregnancy. Advances in technology with lower radiation emissions by dual-energy X-ray absorptiometry instruments now permit the safe...
Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial
isoflavone bone turnover bioavailability probiotics osteopenia postmenopause equol bone density
2018/11/19
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therap...
Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial
isoflavone bone turnover bioavailability probiotics osteopenia postmenopause equol bone density
2018/11/16
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therap...
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone bone estrogen deficiency osteopenia osteoporosis
2018/11/19
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone, bone, estrogen deficiency, osteopenia, osteoporosis
2018/11/16
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
Challenges in defining the role of dietary protein in bone health
Challenges bone health dietary protein
2018/11/14
The systematic review of dietary protein and bone health and falls in the current issue of the Journal by Shams-White et al. (1) is thorough and timely. Their key findings are that dietary protein int...
Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation
protein bone health osteoporosis bone density diet
2018/11/14
Background: Considerable attention has recently focused on dietary protein’s role in the mature skeleton, prompted partly by an interest in nonpharmacologic approaches to maintain skeletal health in a...
Peripheral skeleton bone strength is positively correlated with total and dairy protein intakes in healthy postmenopausal women
bone fragility bone microstructure dairy products finite element analysis fracture risk HR-pQCT nutrition osteoporosis protein intake
2018/11/12
Background: Bone mineral content (BMC) and bone mineral density (BMD) are positively correlated with dietary protein intakes, which account for 1–8% of BMC and BMD variances. However, the relation bet...
Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health
bone density bone turnover half-life obesity vitamin D vitamin D–binding protein
2018/11/30
Background: The mechanism and clinical significance of low circulating 25-hydroxyvitamin D [25(OH)D] in obese people are unknown. Low total 25(OH)D may be due to low vitamin D–binding proteins (DBPs) ...
Moderate weight loss in obese and overweight men preserves bone quality
bone caloric restriction men obesity sex steroids
2018/12/24
Background: Weight loss (WL) negatively affects bone mineral density (BMD) in older populations and has specifically been shown in women.
Visceral adiposity is negatively associated with bone density and muscle attenuation
analytic morphomics bone density computed tomography muscle attenuation visceral adiposity
2018/12/20
Background: The storage of adipose tissue in ectopic compartments is a hallmark attribute linking greater body mass index (BMI) with cardiometabolic diseases. Despite ample evidence to confirm that in...
Visceral adiposity is negatively associated with bone density and muscle attenuation
analytic morphomics bone density computed tomography muscle attenuation visceral adiposity
2018/12/20
Background: The storage of adipose tissue in ectopic compartments is a hallmark attribute linking greater body mass index (BMI) with cardiometabolic diseases. Despite ample evidence to confirm that in...
MIT chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated s...
Adolescent Physical Activity and Bone Strength at the Proximal Femurin Adulthood
HIP STRUCTURAL ANALYSIS PHYSICAL ACTIVITY QUESTIONNAIRE LEAN TISSUE MASS BONE GEOMETRY LONGITUDINAL
2017/5/19
Physical activity (PA) enhances bone structural strength at the proximal femur in adolescence, but whether these benefits are maintained into early adulthood remains unknown. The purpose of this study...