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In Silico Target Prediction by Training Naive Bayesian Models on Chemogenomics Databases
Chemogenomics Databases Informatics
2015/5/26
The completion of Human Genome Project is seen as a gateway to the discovery of novel drug targets (Jacoby, Schuffenhauer, & Floersheim, 2003). How much of this information is actually translated into...
Protein function prediction by integrating sequence, structure and binding affinity information
protein function binding affinity information
2015/5/26
Proteins are nano-machines that work inside every living organism. Functional disruption of one or several proteins is the cause for many diseases. However, the functions for most proteins are yet to ...
Prediction by Partial Matching for Identification of Biological Entities
Identification Partial Matching Prediction
2015/5/26
As biomedical research and advances in biotechnology generate expansive datasets, the need to process this data into information has grown simultaneously. Specifically, recognizing and extracting thes...
USE OF APRIORI KNOWLEDGE ON DYNAMIC BAYESIAN MODELS IN TIME-COURSE EXPRESSION DATA PREDICTION
DYNAMIC BAYESIAN NETWORKS HIDDEN MARKOV MODELS
2015/5/26
Bayesian networks, one of the most widely used techniques to understand or predict the future by making use of current or previous data, have gained credence over the last decade for their ability to ...
Optimizing hydropathy scale to improve IDP prediction and characterizing IDPs' functions
Intrinsically disordered proteins Support vector machine Clustering
2015/5/25
Intrinsically disordered proteins (IDPs) are flexible proteins without defined 3D structures. Studies show that IDPs are abundant in nature and actively involved in numerous biological processes. Two ...
Evaluation of the IrisPlex DNA-based eye color prediction tool in the United States
DNA forensic biology genotype data single nucleotide polymorphisms unknown biological samples the scene of the crime
2015/5/22
DNA phenotyping is a rapidly developing area of research in forensic biology. Externally visible characteristics (EVCs) can be determined based on genotype data, specifically from single nucleotide po...
Rapid and Accurate Protein Side Chain Prediction with Local Backbone Information
side chain prediction local backbone features multiclass
2012/11/30
High-accuracy protein structure modeling demands accurate and very fast side chain prediction since such a procedure must be repeatedly called at each step of structure refinement. Many known side cha...
KU researcher wins international protein prediction competition by wide margin
protein amino acid
2006/12/8
Nov. 21, 2006，LAWRENCE — A University of Kansas researcher has beaten opponents by a wide margin in a competition that could lead to new drug treatments for various illnesses.Protein structures are 3-...