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ABP, a Sertoli cell secretory product, was identified in the seasonal rodent Octodon degus (Molina, 1872). It was shown to be present in cytosols from the testis and epididymis. It migrated with a...
The influence of germ cells (greater than 85% pachytene spermatocytes) on vectorial secretion of androgen binding protein (ABP) and transferrin by immature rat Sertoli cells was investigated using t...
Fractionation of testicular extracts and serum on a Concanavalin A-Sepharose column resolved two peaks of immunoreactive rat androgen binding protein. The rat androgen binding protein in the first pea...
To investigate the relationship between free testosterone and sexual maturation in the male rat, animals were decapitated every 5 days from 25 through 75 days of life. Serum was assayed for androgen...
The indazole carboxylic acid derivative, tolnidamine, has marked antispermatogenic activity in several animal species. In this study, we assessed the effect of tolnidamine on rat Sertoli cell functi...
Sertoli cells were cultured alone or with germ cells to evaluate the effect of the association with germ cells on the secretory activity of Sertoli cells. Secretion of androgen-binding protein, whic...
Gynecomastia and impotence have been described as side-effects of cimetidine therapy. It has previously been shown that cimetidine possesses antiandrogenic properties and competes for dihydrotesto...
The presence of two forms of androgen binding protein (ABP) was confirmed in rat testicular cytosol. Each was distinctly separated from the other by DEAE-cellulose chromatography and showed a sing...
Androgen binding protein (ABP) has been shown to be secreted by Sertoli cells and to be actively taken up by the efferent ducts and proximal caput epididymidis and, yet, to be present at high concen...
The androgen-binding protein (ABP) gene P1 promoter directs cell-specific gene regulation of ABP secreted by Sertoli cells. A recent study using the mouse Sertoli cell line (MSC-1) with a luciferase...
Metabolic cooperation mediated by secreted factors between Sertoli cells and peritubular myoid cells has been well documented. We have confirmed that factors secreted by peritubular myoid cells mo...
This study examines the effects of a potent gonadotropin releasing hormone (GnRH)-antagonist (GnRH-A, Ac-D[2] Nal1, 4-CL-D Phe2, D-Trp3, D-Arg6, D-Ala10) upon the distribution of androgen binding pr...
The amount of androgen-binding protein (ABP) in luminal fluid from the central caput epididymidis of the ram, on a per sperm basis, remains the same as that in rete testis fluid (RTF) entering the...
Androgen-binding protein (ABP) is a testicular glycoprotein (French and Ritzén, 1973; Danzo et al, 1974; Danzo and Black, 1990) that binds androgens with high affinity (Westphal, 1986) and transports ...

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