搜索结果: 1-7 共查到“基础医学 Leptin”相关记录7条 . 查询时间(0.14 秒)
Decreased serum level of soluble-leptin-receptor in patients with systemic lupus erythematosus
Soluble-leptin-receptor Autoantibody Systemic lupus erythematosus Depression
2015/9/28
Background: There is some evidence suggesting that leptin and its negative regulator, soluble-leptinreceptor (SLR) may be able to influence inflammatory and autoimmune processes.
Immunomodulatory role of leptin treatment in experimental sepsis caused by gram negative bacteria
Cytokines leptin myeloperoxidase rat sepsis
2011/3/22
To investigate the effect of leptin treatment on circulating inflammatory cytokines and on tissue damage in experimental rat model of gram-negative sepsis. Materials and methods: Adult male Wistar rat...
In addition to its role in regulating feeding behavior and energy homeostasis, leptin, an adipokine (adipose tissue-secreted cytokine) (1,2), may also control lymphocyte and macrophage functions (3). ...
Leptin对缺氧诱导胎肺Ⅱ型上皮细胞凋亡的影响及机制
瘦素 肺 缺氧 细胞凋亡
2009/6/8
目的： 观察瘦素(LEP)对缺氧诱导胎鼠肺Ⅱ型上皮细胞（AECⅡ）凋亡的拮抗作用，并探讨其机制。方法： 采用改良免疫黏附法原代培养胎鼠AECⅡ细胞，并用SP-A免疫细胞化学法和透射电镜进行鉴定；用含5 mmol/L连二亚硫酸钠（Na2S2O4）培养液培养AECⅡ细胞12 h建立缺氧诱导细胞凋亡模型，处理组含不同浓度LEP（100-1 600 μg/L）；噻唑兰（MTT）比色法检测细胞存活情况；流式...
目的： 研究脓毒症对肝、肾功能及肠道相关酶活性的影响，探讨瘦素（leptin）在急性炎症反应中的作用。方法： 建立小鼠盲肠结扎致脓毒症模型，采用96孔分光光度法检测血清丙氨酸氨基转移酶（ALT）、尿酸（UA）和肠组织匀浆液中髓过氧化物酶（MPO）、谷胱甘肽-S转移酶（GST）、黄嘌呤氧化酶（XOD）、超氧化物歧化酶（SOD）等，同时以HE染色方法观察肠道组织病理学改变。结果： 脓毒症后6 h，血清...
肠缺血/再灌注损伤对leptin及orexin-A水平的影响
2007/7/25
Leptin亦称瘦素、消脂素，是一种包含167个氨基酸、相对分子质量为16 000的脂肪细胞特异性分泌的蛋白，它由ob基因受神经-内分泌系统和能量代谢状况的反馈调节而表达，通过与位于下丘脑的特异受体结合而发挥抑制摄食和促进能量消耗的主要作用[1]。此外，leptin还参与造血、生殖、血管生成及免疫应答[2]。Orexin-A亦称为hypocretin-1，是一种由下丘脑侧部特异神经元分泌的短肽，它...
EFFECTS OF YOHIMBINE ON PLASMA LEVELS OF LEPTIN IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS
Diabetic rats leptin yohimbine insulin adrenoceptor streptozotocin
2010/2/4
Leptin affects paraventricular nucleus of hypothalamus and reduces appetite while activation of α2-adrenoceptors at this site has opposite action. The reducing effect of α2-adrenoceptors inhibition on...