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Mandibular necrosis in beagle dogs treated with bisphosphonates
osteonecrosis bisphosphonates
2014/12/4
Objectives – To test the effect of bisphosphonate (BP) treatment for up to 3 years on bone necrosis and osteocyte death in the mandible using a canine model. Materials and Methods –...
Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia
rodent modeling and remodeling osteoblast
2014/12/4
Recent studies demonstrate that bisphosphonates suppress bone resorption by leading to apoptosis of the osteoclast and inhibiting the differentiation to mature osteoclasts. The influence of bisphospho...
Ovariectomy Stimulates and Bisphosphonates Inhibit Intracortical Remodeling in the Mouse Mandible
BRONJ jaw necrosis osteonecrosis
2014/12/4
Objective – The pathophysiology of osteonecrosis of the jaw (ONJ) is thought to be linked to suppression of intracortical remodeling. The aim of this study was to determine whether mice, ...