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Local Induction of a Specific Th1 Immune Response by Allergen Linked Immunostimulatory DNA in the Nasal Explants of Ragweed-Allergic Subjects
allergen allergic rhinitis CpG motif immunotherapy vaccination
2010/11/16
RW or Amb-a-1 increased the number of IL-4, IL-5, and IL-13 mRNA+ cells in the tissue compared to medium alone. AIC had similar cytokine mRNA reactivity as control tissue. AIC and TT increased IFNγ-mR...
Amb a 1-immunostimulatory Oligodeoxynucleotide Conjugate Immunotherapy Increases CD4+CD25+ T Cells in the Nasal Mucosa of Subjects with Allergic Rhinitis
allergic rhinitis Amb a 1-immunostimulatory oligodeoxynucleotide immunotherapy ragweed-pollen allergy regulatory T cell
2010/11/17
The numbers of allergen-induced CD4+-, CD4+CD25+-, IL-10- and TGF-β-positive cells in the nasal mucosa after AIC immunization before the ragweed season did not differ between the two groups. Repeat ch...