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Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/– mast cells
neurofibromin Schwann cells mast cells
2014/12/12
The NF1 tumor suppressor gene encodes a GTPase-activating protein called neurofibromin that negatively regulates Ras signaling. Mutations in NF1 cause neurofibromatosis type 1 (NF1). The development o...
Targeting Human Mast Cells Expressing G-Protein-Coupled Receptors in Allergic Diseases
allergic diseases bronchial asthma GPCRs human mast cells urticaria
2010/11/17
The G-protein-coupled receptors (GPCRs) are the largest known group of integral membrane receptor proteins and are the most common targets of pharmacotherapy. Mast cells (MCs) have been reported to pl...
Mast Cells in Cutaneous Allergic Vasculitis: A Case Report
allergic cutaneous vasculitis case report immunohistochemical staining leukocytoclastic vasculitis mast cell
2010/11/19
Background: The mechanism of cutaneous allergic vasculitis still remains unclear, and to the best of our knowledge, no case has been reported in the literature in which the number of mast cells was ex...