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Synergistic effects of Isatis tinctoria L. and tacrolimus in the prevention of acute heart rejection in mice
satis tinctoria L mice
2013/6/26
Although immunosuppressive treatments are available for acute cardiac rejection no viable treatment exists for long-term cardiac graft failure. Moreover, the extended use of calcineurin inhibitor immu...
Monoclonal antibody treatment to prolong the secondary cardiac allograft survival in alloantigen-primed mice
Monoclonal antibody mice
2013/6/26
We have previously shown that costimulation blockade using a combination of monoclonal antibodies (mAbs) - CTLA4Ig, antibodies to CD154, LFA-1, and OX40L - can induce tolerance of cardiac allografts i...
Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice
Rapamycin tacrolimus rejection
2013/6/26
Donor-reactive memory T (Tm) cells undermine transplanted organs more readily than naive T cells. Rapamycin (RAPA) and tacrolimus (FK-506) are current mainstay immunosuppressants used for preventing a...
Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice." Transpl Int
ctivation induces islet Suppressing memory
2013/6/26
Summary Memory T cells are known to play a key role in prevention of allograft tolerance in alloantigen-primed mice. Here, we used an adoptively transferred memory T cell model and an alloantigen-prim...
Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice
Isatis molecules prolongs
2013/6/26
Memory T cells present a unique challenge in transplantation. Although memory T cells express robust immune responses to invading pathogens, they may be resistant to the effects of immunosuppressive t...