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Targeted disruption of the cation-dependent or cation-independent mannose 6-phosphate receptor does not decrease the content of acid glycosidases in the acrosome
cation-dependent cation-independent mannose 6-phosphate acid glycosidases acrosome
2008/12/25
The acrosome is a unique organelle containing acid hydrolases common to lysosomes as well as unique enzymes. Its ultimate exocytosis, as well as the absence of several lysosomal markers, has led to ...
Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs
mouse prosaposin gene prostate gland male reproductive organs
2008/12/25
The prosaposin gene encodes a 65-70 kilodalton (kd) protein, which is secreted or targeted to lysosomes. In lysosomes, prosaposin is the precursor of 4 activator proteins, designated saposins A, B...
Cytoskeleton Vimentin Disruption of Mouse Sertoli Cells Injured by Nitrogen Mustard In Vitro
Cytoskeleton Vimentin Disruption Mouse Sertoli Cells Injured by Nitrogen Mustard Vitro
2008/12/24
Reproductive toxicity is one of the potential side effects of anticancer alkylating agents, with potential effects on vimentin intermediate filaments, one of the main components of the Sertoli cytos...