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Acid phosphatase was purified from human prostatic tissue and from seminal plasma. Antisera to antigens from both sources were raised in rabbits. These antisera have been used for immunohistochemical ...
A major determinant of late-life prostate diseases is hormonal exposure during earlier life, but the effects of androgens in midlife on the human prostate have been little studied. In order to ide...
In vitro studies suggest that the protease activity of PSA might play a functional role to facilitate the growth and spreading of cancerous prostatic cells. hK2 may have similar properties. Further ...
Human prostate cancer is initially dependent on androgens for growth, and androgen-dependent cells undergo apoptosis after castration. However, a subset of androgen-responsive cells survives and event...
CCAAT/enhancer-binding protein delta (C/EBPdelta) is a nuclear transcription factor that regulates cellular growth and differentiation. In this study we demonstrate that C/EBPdelta gene expression i...
The growth and dissemination of tumors in the body has been associated with angiogenesis. Vascular endothelial growth factor (VEGF) is an angiogenic factor that stimulates endothelial cell growth and ...
Local biotransformation enzymes and transporter proteins in tissues may exert a profound effect on drug pharmacokinetics in those tissues. Thus, the use of drugs for the treatment of benign prostatic ...
The aim of this study was to evaluate the presence and distribution of retinoid X receptors (RXRs) , ß, and in normal, hyperplastic (nodular, basal cell, and atrophic hyperplasia), and carc...
Retinoic acid receptors (RARs) are nuclear transcription factors that mediate the effects of retinoids. Aberrant expression and regulation of RARs have been linked to various malignancies, including s...

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