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Effects of cyclophosphamide on selected cytosolic and mitochondrial enzymes in the epididymis of the rat
cyclophosphamide selected cytosolic mitochondrial enzymes epididymis rat
2009/2/23
The anticancer and immunosuppressive drug cyclophosphamide is extensively used in clinical practice and is known to alter fertility in man. We showed previously that treatment of male rats with lo...
Are Leydig cell steroidogenic enzymes differentially regulated with aging?
Leydig cells aging steroidogenesis
2009/2/16
Previous studies have shown that the ability of Brown Norway rat Leydig cells to produce testosterone declines significantly with age. To address the possible mechanism(s) by which aging Leydig cell...
Drug-Metabolizing Enzymes and Transporters：Expression in the Human Prostate and Roles in Prostate Drug Disposition
Drug-Metabolizing Enzymes Transporters Human Prostate Prostate Drug Disposition
2008/12/23
Local biotransformation enzymes and transporter proteins in tissues may exert a profound effect on drug pharmacokinetics in those tissues. Thus, the use of drugs for the treatment of benign prostatic ...
Enkephalin-Degrading Enzymes in Normal and Subfertile Human Semen
Opioid peptide peptidase seminal fraction sperm motility sperm death
2008/12/22
Opioid peptides have been reported to have important functions in human reproduction. Indeed, very high concentrations of enkephalins and their degrading enzymes have been reported in human semen. I...
Male Genital Tract Antioxidant Enzymes: Their Source, Function in the Female，and Ability to Preserve Sperm DNA Integrity in the Golden Hamster
Superoxide dismutase glutathione peroxidase catalase sperm DNA damage oxidative stress Syrian hamster
2008/12/19
Recently, we reported that male accessory sex gland (ASG) secretions protect sperm genomic integrity by demonstrating that DNA damage was more extensive in sperm not exposed to the secretions. The p...