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近日,中南大学湘雅医院肿瘤科周蓉蓉教授脑转移MDT团队在国际著名期刊Journal for ImmunoTherapy of Cancer(肿瘤免疫治疗期刊,IF=12.485)以论著形式在线发表了题为“Heterogeneity of tumor immune microenvironment of EGFR/ALK-positive tumors versus EGFR/ALK-negativ...
整合含有天然免疫刺激分子的纳米制剂、以及个性化新抗原筛选技术,使肿瘤疫苗在临床测试展现了令人瞩目的有效性。新一代的肿瘤疫苗与CAR技术﹑免疫检查点干预成为免疫治疗中重要的三大板块。然而,在很多病人中,T细胞无法通过肿瘤屏障进入瘤内,导致对多种免疫治疗的不敏感;因此促进T细胞进入肿瘤,逆转肿瘤微环境成为提高免疫治疗效果的重要步。
Stimulating the body’s immune system to attack tumors is a promising way to treat cancer. Scientists are working on two complementary strategies to achieve that: taking off the brakes that tumors put ...
Sachin Bhagchandani, a graduate student in the Department of Chemical Engineering currently working at the Koch Institute for Integrative Cancer Research, has won the National Cancer Institute Predoct...
癌细胞中程序性死亡配体1(PD-L1)的异常上调抑制T细胞介导的细胞毒性,但驱动和维持PD-L1表达的分子机制仍不完全清楚。PD-L1在肿瘤细胞内高尔基体等细胞器的驻留可能是影响抗体药物疗效的因素之一,但既往对其理解并不充分,使免疫检查点阻断疗法面临挑战。
We are pleased to announce the Cold Spring Harbor Asia conference on Tumor Immunology & Immunotherapy which will be held in Suzhou, China, located approximately 60 miles west of Shanghai. The conferen...
Immunotherapy of melanoma     melanoma  Immunotherapy       2015/3/11
Melanoma is a cruel disease. The most recent Australian figures indicate that over 8000 cases of melanoma were reported in 1997 and that approximately 900 people died of the disease that year+ . O...
CD4+ Th cells, in particular IFN-γ-producing Th1 cells, play a critical role in the activation and maintenance of CD8+ Tc1 cells that are essential for tumor eradication. Recent identification of MHC ...
Hyperthermia is a possible approach for cancer therapy. However, a major technical problem associated with the use of hyperthermia is the difficulty of heating the local tumor region to the intended t...

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