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Efficient adaptive designs with mid-course sample size adjustment in clinical trials
adaptive design conditional power futility Kullback-Leibler information sample size re-estimation
2011/6/17
Adaptive designs have been proposed for clinical trials in which the nuisance parameters
or alternative of interest are unknown or likely to be misspecified before the trial. Whereas most
previous w...
Does adjustment for measurement error induce positive bias if there is no true association?
adjustment measurement error positive bias true association
2010/3/18
This article is a response to an off-the-record discussion that I had at an international meeting of epidemiologists. It centered on a concern, perhaps widely spread, that measurement error
adjustmen...
Adjustment coefficient for risk processes in some dependent contexts
Adjustement coefficient risk process ruin theory non parametricestimation weak dependence
2010/3/17
Following [18], we study the adjustment coefficient of ruin
theory in a context of temporal dependency. We provide a consistent
estimator of this coefficient, and perform some simulations.
Adjustme...