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Discovery of novel regulators of aldehyde dehydrogenase isoenzymes
ALDH2 Characterization High-throughput docking approach
2015/5/25
Recent work has shown that specific ALDH isoenzymes can contribute to the underlying pathology of different diseases. Many ALDH isozymes are important in oxidizing reactive aldehydes resulting from li...
Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (Aldh3a1) as an adjuvant therapy for reversing cancer chemo-resistance
cyclophosphamide chemosensitivity structure activity relationships cell culture
2015/5/25
ALDH isoenzymes are known to impact the sensitivity of certain neoplastic cells toward cyclophosphamides and its analogs. Despite its bone marrow toxicity, cyclophos-phamide is still used to treat var...
Discovery of Novel Regulators of Aldehyde Dehydrogenase Isoenzymes
Aldehyde dehydrogenase high-throughput screening computational docking
2015/1/7
Over the past three years we have been involved in high-throughput screening in an effort to discover novel small molecular modulators of aldehyde dehydrogenase (ALDH) activity. In particular, we have...
Role of aldehyde chemistry and NOx concentrations in secondary organic aerosol formation
aldehyde chemistry NOx concentrations secondary organic aerosol formation
2010/8/16
Aldehydes are an important class of products from atmospheric oxidation of hydrocarbons. Isoprene (2-methyl-1,3-butadiene), the most abundantly emitted atmospheric non-methane hydrocarbon, produces a ...
PPRODUCTION OF AROMATIC ALDEHYDE BY MICROWAVE CATALYTIC OXIDATION OF A LIGNIN MODEL COMPOUND WITH La-CONTAINING SBA-15/H2O2 SYSTEMS
PPRODUCTION OF AROMATIC ALDEHYDE MICROWAVE CATALYTIC OXIDATION LIGNIN MODEL COMPOUND La-CONTAINING SBA-15/H2O2 SYSTEMS
2010/9/20
A convenient and efficient application of heterogeneous La-containing SBA-15 systems for the microwave assisted oxidation of a lignin model phenolic monomer, 4-hydroxy-1-phenylpropane, is reported. Lo...
Genotyping of Polymorphisms in Alcohol and Aldehyde Dehydrogenase Genes by Direct Application of PCR-RFLP on Dried Blood without DNA Extraction
Genotyping Polymorphisms in Alcohol and Aldehyde Dehydrogenase Genes PCR-RFLP Dried Blood DNA Extraction
2010/9/20
We have developed a simple, labor-saving, inexpensive, and rapid single nucleotide polymorphism (SNP) genotyping method that works directly on whole human blood. This single-tube genotyping method wa...
Determination of Linear Short Chain Aliphatic Aldehyde and Ketone Vapors in Air Using a Polystyrene-coated Quartz Crystal Nanobalance Sensor
Linear Short Chain Aliphatic Aldehyde and Ketone Vapors Polystyrene-coated Quartz Crystal Nanobalance Sensor
2010/9/17
A polystyrene coated quartz crystal nanobalance (QCN) sensor was developed for use in the determination of a number of linear short-chain aliphatic aldehyde and ketone vapors contained in air. The qua...
MOLECULAR MODELLING OF HUMAN ALDEHYDE OXIDASE AND IDENTIFICATION OF THE KEY INTERACTIONS IN THE ENZYME-SUBSTRATE COMPLEX
Aldehyde oxidase Molecular modeling 3D-QSAR genetic algorithm
2009/12/25
Aldehyde oxidase (EC 1.2.3.1), a cytosolic enzyme containing FAD, molybdenum and iron-sulphur cluster, is a member of non-cytochrome P-450 enzymes called molybdenum hydroxylases which is involved in t...
Measurement of Aldehyde and VOC Emissions from Plywood of Various Formaldehyde Emission Grades
aldehyde VOC emission small chamber method plywood
2009/3/6
Aldehydes and volatile organic compounds (VOCs) emission from plywood of various formaldehyde emission grades were measured using a small chamber method (JIS A 1901). The effect of the formaldehyde em...
Aldehyde and Volatile Organic Compound Emissions from Laminated Veneer Lumber
LVL formaldehyde VOC small chamber method
2009/3/6
Aldehydes and volatile organic compounds (VOCs) emitted from commercial laminated veneer lumber (LVL) were determined using the JIS small chamber method for 21 days. LVL samples were made from three ...
Determination of Long-chain Alcohol and Aldehyde Contents in the Non-Centrifuged Cane Sugar Kokuto
policosanol aldehyde cane sugar kokuto
2010/2/3
The long-chain alcohol and aldehyde contents and compositions were determined in seven types of the non-centrifuged cane sugar kokuto (Kokuto A to G). Long-chain alcohols, known as policosanols, have ...
乙醛脱氢酶2（ALDH2）基因研究进展及其与饮酒行为的关系Aldehyde Dehydrogenase (ALDH2) Polymorphism and Drinking Behavior*
乙醛脱氢酶2 多态性 饮酒行为
2007/12/7
摘要亚洲人群中普遍存在突变型的乙醛脱氢酶2（ALDH2*2）。此酶突变后活性缺失，导致乙醛在肝脏内大量累积使突变携带者在喝酒后会有脸红等不适反应，因此这可能影响他们的饮酒行为。由于ALDH2*2等位基因与饮酒行为相关，它也可能与酒精引起的肝脏损伤及某些癌症密切相关，而且，它在不同的亚洲人群中有不同的频率分布。近年来对ALDH2*2等位基因的序列结构、表达及其重要功能等有了更深入的了解，对ALDH2...