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近日，生命科学学院沈锡辉教授团队在《Nature Communications》发表了题为“c-di-GMP inhibits the DNA binding activity of H-NS in Salmonella”的研究论文，揭示了细菌第二信使c-di-GMP通过作用于全局性转录调控因子H-NS解除其对基因表达抑制作用的分子机制。生命科学学院博士后李书宇为论文第一作者，沈锡辉教授、张磊教授...
华中农业大学发表细菌第二信使分子c-di-GMP信号通路研究综述（图）
细菌 第二信使分子 c-di-GMP 信号通路
2023/10/18
近日，国际期刊FEMS Microbiology Reviews上在线发表了由华中农业大学农业微生物资源发掘与利用全国重点实验室、湖北洪山实验室何进教授研究团队所撰写的综述论文：“Gas and light: triggers of c-di-GMP-mediated regulation”，该论文总结了c-di-GMP代谢酶感知气体和光信号的调控方式和具体机制，对c-di-GMP信号转导通路的完...
CAMPI FLEGREI | Identificata l’origine delle crescenti emissioni di anidride carbonica（图）
Campania Eartquakes Geologia
2024/12/16
Indagata l’origine dei flussi di anidride carbonica emessi presso la caldera dei Campi Flegrei. Lo studio ha portato ad importanti informazioni sulle dinamiche di degassamento magmatico in corso.
上海交通大学高维强、李力组发现：Di-Ras2——肾癌中一个连接VHL介导泛素化与MAPK通路的新桥梁（图）
上海交通大学 高维强 李力组 Di-Ras2 肾癌 VHL介导 泛素化 MAPK通路 新桥梁
2020/3/31
上海交通大学生物医学工程学院高维强，李力课题组于2020年2月25日在Nature旗下肿瘤学期刊Oncogene上在线发表了研究成果“Di-Ras2 promotes renal cell carcinoma formation by activating the mitogen-activated protein kinase pathway in the absence of von Hipp...
西瓜噬酸菌中C-di-GMP代谢相关基因Aave_2620的功能研究
西瓜噬酸菌 c-di-GMP 功能研究
2021/2/23
环鸟苷二磷酸(cyclic diguanylate,c-di-GMP)是一种广泛存在于植物病原细菌中的第二信使,调控细菌多种生物学功能,从而影响病原细菌的致病性,但其在西瓜噬酸菌中的研究还未见报道。本实验以Aac5菌株为研究对象,通过构建c-di-GMP代谢相关基因Aave_2620缺失突变株和互补菌株,从其致病能力及其生长能力两部分进行测定,探究此信号途径是否在西瓜噬酸菌中调控致病机制。结果表明...
上海交通大学系统生物医学研究院陶生策课题组基于蛋白质芯片发现细菌蛋白质去乙酰化CobB与原核第二信使c-di-GMP间的双向调控通路（图）
上海交通大学系统生物医学研究院 陶生策 蛋白质 芯片 细菌 去乙酰化CobB 原核第二信使 c-di-GMP 双向调控通路
2019/9/9
2019年8月17日，生物化学领域知名期刊The EMBO Journal在线发表上海交通大学系统生物学研究院陶生策课题组最新研究成果Interplay between the bacterial protein deacetylase CobB and the second messenger c-di-GMP，该研究揭示了细菌去乙酰化酶CobB和原核第二信使分子c-di-GMP在体内的相互调控...
基于RNA适配体检测体外酶促合成的c-di-GMP和cGAMP
RNA适配体 c-di-GMP cGAMP 荧光检测
2019/1/16
旨在建立简单、快速的检测体外酶促合成的c-di-GMP和cGAMP的方法。本研究以含有T7启动子、VC2 GEMM-1核糖开关序列或其突变序列VC2/g20a、spinach2和tRNA序列的双链DNA为模板，利用T7 RNA聚合酶体外转录体系制备VC2、VC2/g20a RNA适配体。通过检测绿色荧光强度分析RNA适配体对c-di-GMP和cGAMP的结合能力。结果表明，转录得到的RNA经过加热...
3D GEOMATICS TECHNIQUES FOR AN INTEGRATED APPROACH TO CULTURAL HERITAGE KNOWLEDGE: THE CASE OF SAN MICHELE IN ACERBOLI’S CHURCH IN SANTARCANGELO DI ROMAGNA
Terrestrial Laser Scanner Photogrammetry Structure from Motion Historical Building Information Modelling
2017/6/20
The modern Geomatics techniques, such as Terrestrial Laser Scanner (TLS) and multi-view Structure from Motion (SfM), are gaining more and more interest in the Cultural Heritage field. All the data acq...
病原细菌受体介导的c-di-GMP信号传导及其调控机制
杨凤环 田芳 陈华民 何晨阳
2017/10/20
细菌第二信使环二鸟苷酸(c-di-GMP)信号网络系统主要涉及信号代谢、识别、接受、传递、功能表达和调控。c-di-GMP胞内水平受到鸟苷酸环化酶(DGC)和磷酸二酯酶(PDE)的控制。c-di-GMP信号受体类型多样, 包括转录调控因子、PilZ结构域蛋白、退化的GGDEF和EAL结构域蛋白、核糖体开关、多核苷酸磷酸化酶和新发现的蛋白激酶等。c-di-GMP受体接受信号后, 可以在转录、翻译以及...
Multiple Di fferential Cryptanalysis of Round-Reduced PRINCE (Full version)
Differential cryptanalysis PRINCE multiple differentials
2016/1/26
PRINCE is a lightweight block cipher proposed by Borghoff
et al. at Asiacrypt 2012. Due to its originality, novel design and low number
of rounds, it has already attracted the attention of a large n...
An Improved Truncated Di fferential Cryptanalysis of KLEIN
KLEIN Truncated Differential Attack
2016/1/9
KLEIN is a family of lightweight block ciphers which proposed
at RFIDSec 2011 by Gong et al. It has a 64-bit state and 64, 80 or
96-bit key size which introduce its version. It uses 16 same 4-bit Sb...
Comparison of cube attacks over different vector spaces
Cube/AIDA attack Trivium Linearity testing
2015/12/23
We generalise the cube attack of Dinur and Shamir (and the
similar AIDA attack of Vielhaber) to a more general higher order differentiation
attack, by summing over an arbitrary subspace of the space...
Averaging principle for quasi-linear parabolic PDE’s and related diffusion processes
Quasi linear disturbance two dimensional flow parabola and small parameter
2015/9/28
Quasi-linear perturbations of a two-dimensional flow with a first integral and the corresponding parabolic PDE’s with a small parameter at the second order derivatives are considered in th...
Branching diffusion in inhomogeneous media
Branch diffusion process of particles heterogeneous medium
2015/9/28
We investigate the long-time evolution of branching diffusion processes (starting with a finite number of particles) in inhomogeneous media. The qualitative behavior of the processes depen...
Difference in Difference Meets Generalized Least Squares: Higher Order Properties of Hypotheses Tests
panel data treatment eff ect GLS
2015/9/22
We investigate estimation and inference in difference in difference econometric models
used in the analysis of treatment effects. When the innovations in such models display serial
...