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Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study
epidemiology cognitive function niacin folate vitamin B-6 vitamin B-12 middle age
2018/11/16
Background: Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife.
Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study
epidemiology cognitive function niacin folate vitamin B-6 vitamin B-12 middle age
2018/11/20
Background: Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife.
Correspondence of folate dietary intake and biomarker data
NHANES olate folic acid dietary assessment measurement error prevalence
2018/11/14
Background: Public health concerns with regard to both low and high folate status exist in the United States. Recent publications have questioned the utility of self-reported dietary intake data in re...
Peripheral neuropathy risk and a transcobalamin polymorphism: connecting the dots between excessive folate intake and disease susceptibility
Peripheral neuropathy risk a transcobalamin polymorphism dot disease susceptibility
2018/12/19
Advances in the broad field of nutritional genomics continue to shed light on variable disease susceptibility to modifications in micronutrient intake within populations. This is certainly the case wi...
Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake
folate folic acid peripheral neuropathy TCN2 776C>G polymorphism transcobalamin vitamin B-12
2018/12/19
Background: The 776C→G polymorphism of the vitamin B-12 transport protein transcobalamin gene (TCN2) (rs1801198; Pro259Arg) is associated with a lower holotranscobalamin concentration in plasma. This ...
Applying inappropriate cutoffs leads to misinterpretation of folate status in the US population
deficiency insufficiency microbiologic assay'NHANES'radioprotein-binding assay
2018/12/19
Background: Folate cutoffs for risk of deficiency compared with possible deficiency were originally derived differently (experimental compared with epidemiologic data), and their interpretations are d...
Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study
BRCA BRCA1 BRCA2 breast cancer B vitamins epidemiology folate hereditary breast cancer vitamin B-6 vitamin B-12
2018/12/14
Background: B vitamins [vitamins B-6, B-9 (folate), and B-12] play important roles in nucleotide biosynthesis and biological methylation reactions, aberrancies of which have all been implicated in car...
HIV and other predictors of serum folate, serum ferritin, and hemoglobin in pregnancy: a cross-sectional study in Zimbabwe
Hemoglobin ferritin folate
2016/6/13
Folate and iron status and hemoglobin concentrations
are important to maternal and infant health.
Folate intake of the Dutch population according to newly established liquid chromatography data for foods
Folate folate intake consumption survey
2016/6/13
Determining folate intake is difficult because
existing folate data in food-composition tables are scarce and
unreliable.
Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete
Fasting homocysteine vitamin B-6 riboflavin
2016/6/13
Current data suggest that physiologic doses of
vitamin B-6 have no significant homocysteine-lowering effect.
It is possible that an effect of vitamin B-6 was missed in previous
trials because of a ...
Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use
Homocysteine tHcy folate
2016/6/13
The serum total homocysteine concentration
(tHcy), an indicator of folate status and a possible risk factor for
vascular disease, is elevated with impaired renal function and
poor vitamin B-12 stat...
Serum folate and homocysteine concentrations in large population samples of US ethnic and racial groups
Serum folate homocysteine concentrations
2016/6/2
Two papers, one reporting serum folate concentrations (1) and
one reporting serum homocysteine concentrations (2) in large
population samples of US ethnic and racial groups, appeared
recently in th...
Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women
Race methylmalonic acid homocysteine
2016/6/2
Many previous investigations of cobalamin and
folate status were performed in white populations.
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
folate homocysteine mutation
2016/6/1
Down syndrome, or trisomy 21, is a complex
genetic disease resulting from the presence of 3 copies of chromosome
21. The origin of the extra chromosome is maternal in
95% of cases and is due to the...
Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome
homocysteine metabolism gene polymorphisms
2016/6/1
One of the major advances in preventing malformations in the
past few decades had its origin in the observation by Smithells et
al (1) that multivitamin preparations are protective against neural
t...