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Pyrimido-Pyrimidines: A Novel Class of Dihydrofolate Reductase Inhibitors
dihydrofolate reductase docking, inhibitors pyrimido[4,5-d]pyrimidine-2,4-diamine
2010/2/1
Inhibitors of dihydrofolate reductase (DHFR), an enzyme that catalyzes 5,6,7,8-tetrahydrofolate synthesis, have been used as antimicrobial as well as antimetabolite drugs for a long time. Although str...
Neural Tube Defects and 19 bp Deletion Within Intron-1 of Dihydrofolate Reductase Gene
Neural tube defects spina bifida dihydrofolate reductase
2009/6/16
Aims: Dihydrofolate reductase (DHFR) is necessary for the reduction of the ingested folates before they are used in the body metabolism. Thus, the DHFR enzyme has an important role in folate supplemen...
A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users
Folate dihydrofolate reductase DHFR one-carbon metabolism breast cancer multivitamins prospective study
2008/12/12
Background:Dihydrofolate reductase (DHFR) converts dihydrofolate (DHF) into tetrahydrofolate (THF) and plays an essential role in cell metabolism and cellular growth. Folic acid from multivitamins nee...