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中药组方优化试验设计方法概述
中药 组方优化 试验设计 数理模型
2021/3/30
组方优化研究是中药方剂研究的重要环节，是中兽药产业化推广的关键步骤。本文介绍了中药组方的概念、组方优化的原则、目的、意义及指导思想等，总结了近年来基于中医传统理论和现代数理模型的两类中药组方优化方法，进一步对其中基于现代数理模型的试验设计方法，包括正交设计、均匀设计、基线等比设计、Plackett-Burman筛选试验设计、星点设计、中心组合设计、Doehlert设计等进行比较，并分析了不同方法在...
不同产源艾纳香油抗菌活性筛选及其对金黄色葡萄球菌抗菌作用的研究
艾纳香油 GC-MS 化学成分 抗菌活性
2021/3/5
旨在筛选抗菌效果好的艾纳香油，寻找其抗菌活性物质，分析其对金黄色葡萄球菌抗菌作用。通过对金黄色葡萄球菌、大肠杆菌、铜绿假单胞杆菌、无乳链球菌、白色念珠菌体外抗菌试验筛选不同产源（A1~A5）和自制的艾纳香油（B1~B9、T），采用GC-MS分析主要化学成分，并检测其部分化合物对金黄色葡萄球菌、铜绿假单胞杆菌的最小抑菌浓度（MIC）和最小杀菌浓度（MBC），采用金黄色葡萄球菌感染小鼠模型研究艾纳香油...
旨在研究酶法辅助技术提取沙苑子三萜的工艺及体外抗氧化活性。在单因素实验的基础上，确定液料比、酶添加量、酶解温度、酶解时间4 个因素的Box-benhnken 的实验设计，以三萜的提取率为响应值，采用响应面法优化沙苑子三萜的提取工艺，建立并分析各因素与指标值的数学模型；采用自由基清除能力体系评价沙苑子三萜的抗氧化活性。优化分析所得的最佳工艺参数为：液料比为40 mL/g，酶添加量为500 μg/mL...
Evaluation of diagnostic coelioscopy including liver and kidney biopsies in cinereous vultures (Aegypius monachus)
biopsy avian endoscopy minimally invasive endosurgery large raptor
2016/12/8
Diagnostic coelioscopy, including liver and kidney biopsies, was performed in seven cinereous vultures (Aegypius monachus). A 5-mm endoscopy system was used for examination of coelomic viscera. The en...
Influence of dexmedetomidine-propofol-isoflurane and medetomidine-propofol-isoflurane on intraocular pressure and pupil size in healthy dogs
alpha-2 agonist premedication eye ophthalmology
2016/12/8
The present prospective, randomised, double-blinded clinical study was designed to investigate the commonly used anaesthetic combinations of dexmedetomidine-propofol-isoflurane and medetomidine-propof...
Comparison of qualitative and quantitative properties of the wings,necks and offal of chicken broilers from organic and conventional production systems
meat quality broiler chemical indicators liver heart gizzard
2016/12/8
The aim of the present study was to investigate qualitative and quantitative properties of wings, offal (liver, heart and gizzard) and necks of chickens from organic and conventional production system...
Mesh repair of a large ventral hernia with interposition of omentum in a calf:a case report
bovine soft tissue surgery herniorraphy adhesion polypropylene
2016/11/11
A one-month-old, Piedmontese female calf was admitted to the Department of Veterinary Sciences, University of Turin, for repair of a large ventral hernia. A large ventral hernia, approximately 20 cm l...
Corpus luteal angiogenesis in a high milk production dairy breed differs from that of cattle with lower milk production levels
Holstein Friesian dairy cows dual purpose cows corpus luteum vascularisation capillary angiogenesis
2016/10/14
Globally, high producing, young dairy cows often have health and fertility problems such as ovarian, uterine and placental dysfunction, mastitis and impaired wound healing. These health issues can res...
Shape memory compression anastomosis clips in gastrointestinal surgery in dogs
CAC intestinal anastomosis NiTi animals
2016/10/14
This paper describes clinical experiences with the use of shape memory nickel-titanium (NiTi) clips in gastrointestinal surgery in dogs. Side-to-side small bowel anastomosis was performed in eight dog...
Effects of acetylsalicylic acid on coagulation tests and haptoglobin concentrations in rabbits with permanent transvenous pacing
inflammation D-dimers pacemaker Oryctolagus
2016/10/14
The aim of this study was to evaluate changes in coagulation tests, haptoglobin concentrations and leukocyte counts in rabbits with right-ventricle pacing medicated with acetylsalicylic acid (ASA). Bl...
Cutaneous leiomyosarcoma with osteoid metaplasia in a budgerigar (Melopsittacus undulatus):a case report
desmin CD68 smooth muscle actin spindle-shaped cells S100
2016/10/14
Cutaneous leiomyosarcoma with osteoid metaplasia was diagnosed at the base of the right wing in a five-year-old female budgerigar. Grossly, the tumour mass was well circumscribed and solitary, and had...
Radiographic findings in sheep with abomasal phytobezoariasis
phytobezoar abomasography radiography barium abomasum abomasotomy
2016/9/1
The purpose of this study was to characterise the radiographic appearance of abomasal phytobezoars in sheep as well as to evaluate the utility of abdominal radiography to identify them. Twenty-seven f...
Pectus excavatum in a cat:a case report
cat pectus excavatum external splint surgical correction
2016/8/2
This case report aims to clinically and radiologically describe a case of feline pectus excavatum and to evaluate the treatment results. An 8-month-old female cat weighing 3.2 kg was presented to the ...
旨在研究肉鸡腹水综合征发生发展过程中的肺组织EGFL7、VEGF和VEGFR2等血管内皮细胞源性增殖因子表达量的变化和复方中药对其影响。275羽8日龄罗斯肉鸡随机分为空白组（常规饲养），模型组（9~11 ℃，饲料中添加3%猪油和4%鱼粉，饮水中添加0.12% NaCl），复方中药高、中、低剂量组（饲养同模型组，每天于饮水中分别给予2、1、0.5 mL•kg－1复方中药），用荧光定量PC...
Feline obesity–prevalence,risk factors,pathogenesis,associated conditions and assessment:a review
overweight obese body condition cat
2016/7/6
Obesity is recognised as the most common multiffactorial nutritional disorder of pet cats. Studies from several countries have indicated that between 11.5% and 63% of cats are overweight or obese. Bre...