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Synthesis, structural determination, and biological activity of new 7-hydroxy-3-pyrazolyl-4H-chromen- 4-ones and their o-b-D-glucosides
Chromones pyrazoles glucopyranosyl bromide glucosylation
2010/10/15
A convenient route to synthesize some new medicinally important 7-hydroxy-3-pyrazolyl chromones (3a-i) is described. The interaction of 7-hydroxy-3-formyl chromone (1) with various substituted acetoph...
Synthesis, Characterization and Biological Applications of Organotin(IV) Derivatives of 2-(2-Fluoro-4-biphenyl)propanoic Acid
Synthesis Characterization Biological 2-(2-Fluoro-4-biphenyl)propanoic Acid
2010/4/21
A series of organotin(IV) derivatives with the general formula R4 - nSnLn (where n = 1 or 2, R = Me, Et, n-Bu, Ph and L = 2-(2-fluoro-4-biphenyl)propanoate) have been synthesized and characterized by ...
Synthesis and Biological Activity of 4-(4-Hydroxybenzylidene)-2- (substituted styryl) oxazol-5-ones and Their o-glucosides
Oxazolone a -acetobromoglucose decetylation o-glucosides antimicrobial antifungal activity
2010/4/9
The 4-(4-hydroxybenzylidene)-2-methyl oxazol-5-ones 1 were treated with various aldehydes in the presence of acetic acid to form 4-(4-hydroxybenzylidene)-2-(substituted styryl) oxazol-5-ones 2a-i, whi...
Synthesis and Biological Activity of Allosteric Modulators of GABAB Receptors. Part 4. Synthesis of Potentially Fluorescent Acridines and Conformationally Restricted N-(arylpropyl)-1-arylethylamines
Fendiline analogues acridines acridones aminotetralins aminoindanes GABA
2010/4/15
A series of 8 new derivatives of fendiline was prepared for evaluation as allosteric modulators of GABAB receptors: 4 based on acridine and 4 with restricted distance between the 2 aryl moieties.
Synthesis, Spectroscopic and Biological Investigation of Cyclic Octapeptide: Cherimolacyclopeptide G
Cyclic octapeptide cherimolacyclopeptide G antibacterial activity antifungal activity anthelmintic activity cytotoxicity
2010/4/16
A natural cyclic octapeptide cherimolacyclopeptide G (8) was synthesized by coupling of tetrapeptide units Boc-Gly-Ala-Val-Pro-OMe (5) and Boc-Ile-Tyr-Ala-Pro-OMe (6) after proper deprotection at carb...
Synthesis and Biological Activities of N-Alkyl Derivatives of o-, m-, and p-Nitro (E)-4-Azachalcones and Stereoselective Photochemistry in Solution, with Theoretical Calculations
Nitro-(E)-4-azachalcones nitro-(E)-N-decyl-4-azachalconium bromide photodimerisation antimicrobial and antioxidant activities
2010/4/19
The N-alkyl derivatisation and photochemical dimerisation of 3 o-, m-, and p-nitro substituted 4-azachalcones (1-3) yielded 3 new o-, m-, and p-nitro substituted (E)-N-decyl-4-azachalconium bromides, ...
Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation
Sonogashira reaction 4-ipomeanol cytotoxic activity MTT assay
2010/4/19
The thiophene analogue of (\pm)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisa...
Organotin (IV) Derivatives of 1-Ethyl-1,4-Dihydro-7-Methyl-4-Oxo- 1,8-Naphthyridine-3-Carboxylic Acid (Nalidixic Acid): Synthesis, Structural Elucidation and Biological Activities
Organotin(IV) complexes 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8- naphthyridine-3-carboxylic acid (nalidixic acid) Spectroscopic characterization Biological Activity
2010/4/19
Organotin carboxylates of the general formulae R2SnL2 and R3SnL, where R = CH3, n-C4H9, C6H5, CH2C6H5 and L = 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (nalidixic acid), h...
New Complexes of Organotin(IV) 2-(N-Maleoylamino)-2-methylpropanoate: Synthesis, Spectroscopic Characterization and Biological Activity
Organotin(IV) carboxylates spectroscopic studies biological activity
2010/4/20
Organotin(IV) complexes of 2-(N-maleoylamino)-2-methylpropanoate were prepared by treating the ligand acid with diorganotin dichloride and triorganotin chloride in 1:2 and 1:1 molar ratios, respective...
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications
Derivatives Synthesis Spectroscopic Characterization Biological Applications
2010/4/20
Some new di- and tri-organotin(IV) derivatives of 4 different non-steroidal anti-inflammatory drugs (NSAIDs) with the general formulae R2SnL2 and R3SnL (where R = n-C8H17 and C6H5CH2) and L = 2-[(2,3-...
Secondary Metabolites of Phlomis viscosa and Their Biological Activities
Phlomis viscosa iridoids phenylethanoid glycosides lignan glucosides 8-O-4'-oxylignan neolignan glucosides biological activity
2010/4/20
Further phytochemical studies on the aerial parts of Phlomis viscosa (Lamiaceae) led to the isolation of 24 compounds: 3 iridoid glycosides, 10 phenylethanoid glycosides, a megastigmane glycoside and ...
1H, 13C, 119Sn NMR, Mass, Mössbauer and Biological Studies of Tri-,Di- and Chlorodiorganotin(IV) Carboxylates
1H 13C 119Sn NMR Mass Mö ssbauer Biological Studies
2010/4/21
The reaction of 2-[(2,3-dimethylphenyl)amino]benzoic acid (HL) with tri- and diorganotin(IV) chlorides yielded complexes of the type R3SnL and R2SnL2 (R = n-C4H9, C6H5, C6H5CH2, n-C8H17). The compound...
Synthesis, Spectral Characterization and Biological Applications of Tri- and Diorganotin(IV) Derivatives of 2-[N-(2,6-Dichloro-3-methylphenyl)amino]benzoic acid
Synthesis Spectral Characterization Biological Applications
2010/4/21
A series of tri- and diorganotin(IV) compounds with the general formulae R3SnL and R2SnL2 (where R = Me, n-Bu, Ph and L = 2-[N-(2,6-dichloro-3-methylphenyl)-amino]benzoate) were synthesized. These com...
Synthesis, Characterization and Biological Applications of Organotin(IV) Derivatives of 2-(2-Fluoro-4-biphenyl)propanoic Acid
Synthesis Characterization Biological 2-(2-Fluoro-4-biphenyl)propanoic Acid
2010/4/21
A series of organotin(IV) derivatives with the general formula R4 - nSnLn (where n = 1 or 2, R = Me, Et, n-Bu, Ph and L = 2-(2-fluoro-4-biphenyl)propanoate) have been synthesized and characterized by ...