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Light-activated 'CRISPR' enables fast, precise gene editing and detection of DNA repair（图）
Light-activated CRISPR enables fast precise gene editing detection DNA repair
2020/7/3
In a series of experiments co-funded by the National Science Foundation, scientists at Johns Hopkins have used light as a trigger to make quick, precise cuts in the genomic material of ...
Directly Reprogramming a Cell's Identity with Gene Editing
Reprogramming Cell Identity Gene Editing
2016/8/23
Researchers have used CRISPR—a revolutionary new genetic engineering technique—to convert cells isolated from mouse connective tissue directly into neuronal cells.In 2006, Shinya Yamanaka, a professor...
Maternal thyroid hormone regulates gene expression in the fetal rat brain
Clinical thyroid hormone the fetus gene
2014/12/11
Recent clinical evidence indicates that thyroid hormone plays an essential role in fetal brain development. However, the mechanism by which thyroid hormone affects development has been largely unexplo...
Energy availability signals and the prohormone convertase 1 gene are regulated by Nhlh2
Gene regulation signals transcription factors leptin thalamus arcuate nucleus neurons
2014/12/11
Body weight is controlled by gene regulation through the activation of signal transduction pathways which ultimately regulate transcription factors and their gene targets. Fluctuating leptin levels re...
Novel developmental functions of the Drosophila SOX gene Dichaete
Cell biology a fertilized egg embryo cell state factor regulation gene subset of mammalian proteins
2014/12/11
All multicellular life begins as a single cell—the fertilised egg, from which the adult organism develops. As a general priniciple, as embryos progess through development, changes in cellular status s...
Identification and Functional Characterization of the Zebrafish Gene Quetschkommode (que)
dbt disease models metabolism MSUD neurodegenerative diseases zebrafish
2014/12/10
Locomotion in vertebrates depends on proper formation and maintenance of neuronal networks in the hind-brain and spinal cord. Malformation or loss of factors required for proper maintenance of these n...
Gold nanoparticles help target, quantify breast cancer gene segments in a living cell
Gold nanoparticles help target, quantify breast cancer gene segments in a living cell
2014/5/13
Alternative messenger RNA (mRNA) splicing is a fundamental process of gene regulation, and errors in RNA splicing are known to be associated with a variety of different diseases. However, there is cur...
Breast Cancer Cells Less Likely to Spread When One Gene is Turned Off（图）
Turned Off Breast Cancer Cells Less
2014/3/20
COLUMBUS, Ohio – New research suggests that a protein only recently linked to cancer has a significant effect on the risk that breast cancer will spread, and that lowering the protein’s level in cell ...
Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-depleted Murine Embryonic Stem Cells
Mapping Dynamic Histone Acetylation Patterns Gene Expression in Nanog-depleted Murine Embryonic Stem Cells
2010/11/15
Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance of pluripotency ...
New gene discovered in human stem cells may benefit transplant patients
stem cells blood cancer
2007/4/27
26 April 2007，Oxford scientists have for the first time revealed a link between a gene and the activity of human stem cells, giving hope that stem cell transplant success for blood cancer patients may...