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Differences in T cells’ functional states determine resistance to cancer therapy（图）
T细胞 癌症治疗 耐药性
2023/6/6
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in humans. Some patients with NSCLC receive a therapy called immune checkpoint blockade (ICB) that helps kill cancer cells by ...
How A Tumor Grows Can Predict Response To Cancer Therapy（图）
Tumor Grows Predict Response Cancer Therapy
2018/1/10
Individual tumors respond differently to cancer drugs, if at all. Until now, it remained a mystery why tumors have different reactions to the exact same therapy. But a new study at the USC Viterbi Sch...
Inhibition of Ape1's DNA Repair Activity as a Target in Cancer: Identification of Novel Small Molecules that have Translational Potential for Molecularly Targeted Cancer Therapy
Cancer Chemotherapy Base Excision Repair DNA Repair
2015/5/25
The DNA Base Excision Repair (BER) pathway repairs DNA damaged by endogenous and exogenous agents including chemotherapeutic agents. Removal of the damaged base by a DNA glycosylase creates an apurini...
An exhaustive analysis has been conducted of more than 12,000 distinct proteins present in an often aggressive and difficult to treat form of breast cancer, called triple-negative breast cancer.The re...
Impact of gene technologies on personalised cancer therapy
gene technologies personalised cancer therapy
2015/3/26
Given that cancer is driven by inherited and acquired defects in our genetic code, the ability to profile genes and their activities has the potential to impact substantially on the prevention and tre...
A large number of monoclonal antibodies (mAbs) are currently
under investigation for the treatment of malignant diseases. To
date, a significant amount of experimental and clinical research
had bee...
UQ researcher Dr Kris Thurecht is developing new molecules to potentially improve the performance of cancer therapy by delivering drugs directly to cancers. Dr Thurecht was awarded a $90,000 UQ Founda...
Pharmacists' Role in Targeted Cancer Therapy in Australia and Implications for Pharmacy Education
cancer targeted therapy monoclonal antibody genomic medicine pharmacodiagnostics
2018/5/24
Objectives. To investigate the pharmacists' role in providing targeted therapies to patients and its implications for pharmacy education.
Methods. Nine pharmacy faculty members, 12 clinical pharmacis...
Breast cancer stemlike cells and breast cancer therapy
Breast cancer stem cells Signaling pathway Resistance
2012/7/13
Until the early 1990s, human cancers were considered a morphologically heterogeneous population of cells. In 1997, Bonnet et al demonstrated that a small population of leukemia cells was able to diffe...
Role of molecular markers in breast cancer therapy
Breast neoplasms Therapy Prognostication Prediction
2012/7/13
Translational research, in general, means to take knowledge from one area into a second. Traditional thought to represent transfer of knowledge from basic research into the clinic, translational resea...
Current status of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) targeting cancer therapy
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) TRAIL receptor 1 (TRAIL-R1), TRAIL receptor 2 (TRAIL-R2) apoptosis KM mouseTM monoclonal antibody targeting therapeutics
2009/7/15
Monoclonal antibodies have already established a secure position as a very promising strategy for anti-tumor therapeutics. High specificity and high affinity are attractive characteristics of antibodi...
Combined Cancer Therapy of Ultrasound and Drug Delivery
Cancer Therapy Ultrasound Drug Delivery
2009/6/9
Combined Cancer Therapy of Ultrasound and Drug Delivery.
Compact Cancer-Therapy Particle-Delivery System Patented
Cancer-Therapy Particle-Delivery System
2009/5/20
UPTON, NY — As part of an effort to make high-precision particle cancer therapy accessible to more patients, a physicist at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory has dev...
New Advance in Caspase-Independent Programmed Cell Death and Its Potential in Cancer Therapy
apoptosis autophagy cancer therapy caspase-independent programmed cell death
2009/4/20
Caspase activation has been frequently viewed as synonymous with programmed cell death (PCcD); however, accumulating evidence showed that there existing caspase-independent PCcD pathways displaying m...
Investigations of the Telomerase Template Antagonist GRN163L and Implications for Augmenting Breast Cancer Therapy
GRN163L Telomerase Breast Cancer
2015/5/21
Breast cancer is the second most common cancer among women in the US after skin cancer. While early detection and improved therapy has led to an overall decline in breast cancer mortality, metastatic ...