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My valedictory on the differences in biolog-ical potency between RRR-α-tocopheryl and all-rac-α-tocopheryl acetate
RRR-α-tocopheryl all-rac-α-tocopheryl acetate
2016/5/30
In their study, Marshall et al (1) found a significant relation
between serum LDL cholesterol and saturated fat intake when
random-effects models for longitudinal data were used. The
model paramete...
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
Rac Cdc42
2014/12/12
Critical to homeostasis of blood cell production by hematopoietic stem/progenitor (HSC/P) cells is the regulation of HSC/P retention within the bone marrow microenvironment and migration between the b...
Rac Activation Induces NADPH Oxidase Activity in Transgenic COSphox Cells and Level of Superoxide Production is Exchange Factor-Dependent
NADPH oxidase Rac
2014/12/12
Transient expression of constitutively active Rac1 derivatives, (G12V) or (Q61L), was sufficient to induce phagocyte NADPH oxidase activity in a COS-7 cell model in which human cDNAs for essential oxi...
Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo: Role of the C-terminal polybasic domain
Rac GTPase NADPH oxidase
2014/12/12
The Rho family GTPase Rac acts as a molecular switch for signal transduction to regulate various cellular functions. Mice deficient in the hematopoietic-specific Rac2 isoform exhibit agonist-specific ...
Rac及其下游靶蛋白p21活化激酶(PAK)均是最近新发现的多功能效应因子，与多种肿瘤的发生、发展密切相关。PAK主要通过其N端调节/黏附区的p21结合域(PBD)与上游调节器Rac相互作用从而使Rac/PAK信号通路激活，在结直肠癌的发生、发展、侵袭及转移中发挥重要的作用。随着研究的深入，越来越多的证据表明Rac/PAK信号通路不仅可以作为一种预测因子来判断结直肠癌的恶性进展及估计预后并且可能成...
探讨谷胱甘肽S转移酶π（GST-π）和Ras相关的C3肉毒素底物1（Rac-1）在肝细胞性肝癌（HCC）中的表达水平及其与临床病理参数和预后的关系。方法：应用免疫组织化学法检测82例HCC组织和30例正常肝组织中的GST-π和Rac-1表达，依据阳性细胞计数与染色强度相结合的二级计分法将两蛋白均分为高表达和低表达两组，分析该两组与常见病理参数的关系及两蛋白的相关性；采用Kaplan-Meier生存...
Incorporation of deuterated RRR- or all-rac-α-tocopherol in plasma and tissues of α-tocopherol transfer protein–null mice
Vitamin E deuterium-labeled α-tocopherol α-TTP knockout mice mass spectrometry vitamin E requirement liver brain
2016/12/17
Background: Most vitamin E supplements contain synthetic all-rac-α-tocopherol [2,5,7,8-tetramethyl-2RS-(4′RS,8′RS,12-trimethyltridecyl)-6-chromanol] with 8 stereoisomers; only 1 is identical...