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Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism
glucose tolerance high-carbohydrate diet stable isotopes
2016/6/13
High-carbohydrate diets improve plasma cholesterol
concentrations but increase triacylglycerol concentrations;
the latter effect increases the risk of cardiovascular disease
(CVD). Triacylglycerol ...
Effects of chronic alcohol treatment on the synthesis, sialylation, and disposition of nascent apolipoprotein E by peritoneal macrophages of rats
Chronic ethanol feeding macrophages apolipoprotein E glycosylation sialylation sialic acid content
2016/6/7
Background: Plasma apolipoprotein (apo) E, a sialoprotein,
plays an important role in reverse cholesterol transport. Previously,
we showed that chronic alcohol consumption impairs glycosylation
of ...
Determination of glutamine in muscle protein facilitates accurate assessment of proteolysis and de novo synthesis–derived endogenous glutamine production
Glutamine glutamic acid muscles
2016/6/1
Results of tracer studies indicate that skeletal muscle
contributes to <70% of overall glutamine production in
healthy adults; the contribution of de novo synthesis being estimated
at <60%. However...
Daily Overfeeding from Protein and/or Carbohydrate Supplementation for Eight Weeks in Conjunction with Resistance Training Does not Improve Body Composition and Muscle Strength or Increase Markers Indicative of Muscle Protein Synthesis and Myogenesis in Resistance-Trained Males
Protein carbohydrate muscle strength hypertrophy muscle protein synthesis myogenesis
2016/3/11
This study determined the effects of heavy resistance training and daily overfeeding with carbohydrate and/or protein on blood and skeletal muscle markers of protein synthesis (MPS), myogenesis, body ...
Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis
Nitric oxide L-citrulline L-arginine Glutathione Resistance exercise
2015/7/30
Nitric oxide (NO) is endogenously synthesized from L-arginine and L-citrulline. Due to its effects on nitric oxide synthase (NOS), reduced glutathione (GSH) may protect against the oxidative reduction...
RNA Synthesis in the Tracheal Epithelial Cells of Aging Mice as Revealed by Electron Microscopic Radioautography
RNA synthesis Macromolecular Microscopic radioautography 3H-uridine
2015/7/21
For the purpose of studying the aging changes of macromolecular synthesis in the tracheal epithelial cells of experimental animals, we studied 10 groups of aging mice during development and aging from...
Solid-Phase Synthesis of N-Carboxyalkyl Unnatural Amino Acids
solid-phase synthesis amino acids combinatorial chemistry
2015/5/21
A novel route has been developed for the solid-phase synthesis of N-carboxyalkyl unnatural amino acids as potential metalloprotease inhibitors. The key step involves a nitrogen alkylation of resin-bou...
The Relationships Between Simulated Tennis Performance and Biomarkers for Nitric Oxide Synthesis
Blood lactate heart rate nitric oxide stroke performance tennis
2015/5/15
Tennis performance requires a good aerobic endurance and recovering capacity. Nitric oxide (NO) is a gas which is not only a vasodilator and antioxidant but it also regulates the use of oxygen and glu...
The Role of Post-Exercise Nutrient Administration on Muscle Protein Synthesis and Glycogen Synthesis
Protein supplementation carbohydrate supplementation anabolism
2015/5/5
Nutrient administration following an exercise bout vastly affects anabolic processes within the human body, irrespective of exercise mode. Of particular importance are protein and carbohydrates whereb...
Design and Implementation of a Laboratory-Based Drug Design and Synthesis Advanced Pharmacy Practice Experience
APPE research drug design synthesis medicinal chemistry
2018/8/17
Objective. To provide students with an opportunity to participate in medicinal chemistry research within the doctor of pharmacy (PharmD) curriculum.
Design. We designed and implemented a 3-course seq...
Regulation of Muscle Glycogen Repletion, Muscle Protein Synthesis and Repair Following Exercise
Carbohydrate nutrients insulin glucose amino acids
2015/3/13
Recovery from prolonged strenuous exercise requires that depleted fuel stores be replenished, that damaged tissue be repaired and that training adaptations be initiated. Critical to these processes ar...
Synthesis and Mechanistic Studies of a Novel Homoisoflavanone Inhibitor of Endothelial Cell Growth
Endothelial Cell Growth Synthesis and Mechanistic
2014/11/25
Preventing pathological ocular angiogenesis is key to treating retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. At present there is no small molecule drug on the ...
Synthesis and Influence of Two Quinoxalinone Derivatives on Anxiety- and Depressive-Like Responses in Wistar Rat
Depression Anxiety Quinoxalinone Derivatives Locomotor Activity Wistar Rats
2013/1/30
Two new quinoxalinone derivatives have been synthesized adopting the HONG method, and investigated for some neuropharmacological effects (anxiety- and depressive-like responses) in rats. The present e...
Total Synthesis of (±)-Decursivine and (±)-Serotobenine: A Witkop Photocyclization/Elimination/O-Michael Addition Cascade Approach
Total Synthesis of (±) Decursivine and (±)-Serotobenine A Witkop Photocyclization/Elimination/O-Michael Addition Cascade Approach
2012/7/3
Decursivine和Serotobenine是一类具有苯并二氢呋喃，吲哚并八元内酰胺多环体系的吲哚生物碱，分别具有抗疟疾及广泛的抗菌活性，其良好的生物活性和独特新颖的结构，引起了合成化学家的关注。其中Michael A. Kerr小组以18步3%的总收率首次完成了(±)-Decursivine的全合成，Tohru Fukuyama小组以24步8%的总收率首次完成了(-)-Serotobenin...
Synthesis of metronidazole derivatives as antigiardiasis agents
Metronidazole Giardiasis Imidazole Epoxide
2010/4/6
Metronidazole (MTZ) and its derivatives have been extensively used to treat infections caused by protozoa and anaerobic bacteria. In this investigation several novel imidazole and nitroimidazol deriva...