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Mutations in the gene encoding retinol binding protein and retinol deficiency: is there compensation by retinyl esters and retinoic acid?
retinyl esters retinoic acid
2016/5/31
Biesalski et al (1) present a novel case of 2 sisters aged 14 and
17 y with very low plasma retinol concentrations (0.19 mmol/L)
and plasma concentrations of retinol binding protein (RBP) below
the...
Interaction between cellular retinoic acid-binding protein II and histone hypoacetylation in renal cell carcinoma
Retinoic acid Cellular retinoic acid-binding proteins Histone deacetylase Renal cell carcinoma
2015/7/28
Renal cell carcinoma is a rare but serious malignancy. Since a reduction in the level of retinoic acid receptor beta 2 (RARbeta2) expression in cancer cells due in part to histone hypoacetylation whic...
Expression Analysis of DEK, AF4 and FLI1 Genes in All-Trans-Retinoic Acid (ATRA) Treated Acute Promyelocytic Leukaemia t(15;17) Patients by Quantitative Real-Time PCR
DEK AF4 FLI1 Acute Promyelocytic Leukemia All-Trans-Retimic Acid
2009/6/23
All-trans retinoic acid (ATRA) sensitivity of acute promyelocytic leukaemia (APL) cells is strictly dependent on the presence of t(15;17), but the molecular background of this sensitivity remains obsc...
Expression of Retinoic Acid Receptor (RAR) α Protein in the Synovial Membrane from Patients with Osteoarthritis and Rheumatoid Arthritis
osteoarthritis rheumatoid arthritis retinoic acid receptor synovial membrane
2009/4/20
Retinoic acid receptors (RAR) are expressed in inflammatory cells and, through ligand binding, play an important role in cell proliferation and differentiation, as well as in regulation of cytokine an...
Identification of copper-binding nuclear proteins in mouse brain: its involvement in retinoic acid receptor signaling
copper-binding nuclear proteins mouse brain retinoic acid receptor signaling
2009/4/1
Copper is an essential micronutrient with numerous cellular functions. Previous studies have demonstrated that copper deficiency in P19 embryonal carcinoma cells by using a copper depletor, bathocupro...
Effect of retinoic acid-induced transglutaminase on cell growth in regenerating liver
retinoic acid-induced transglutaminase cell growth regenerating liver
2009/3/2
Transglutaminase 2 (TG2) is implicated in the inhibitory regulation of the hepatocyte growth in vitro. In vivo, however, the role of TG2 in liver regeneration after partial hepatectomy (PH) is almos...
Localization of cellular retinol-binding protein and cellular retinoic acid-binding protein in the rat testis and epididymis
cellular retinol-binding protein cellular retinoic acid-binding protein rat testis
2009/2/20
The distribution of cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP) in rat testis and epididymis was examined by the peroxidase-antiperoxidase immunolocali...
Immunohistochemical Localization of the Retinoic Acid Receptors in Human Prostate
Immunohistochemical Localization Retinoic Acid Receptors Human Prostate
2008/12/15
Retinoic acid receptors (RARs) are nuclear transcription factors that mediate the effects of retinoids. Aberrant expression and regulation of RARs have been linked to various malignancies, including s...
视黄类受体与视黄酸致畸作用关系Relations between the Retinoic Acid Acceptor and Teratogenesis of Retinoids
视黄类受体 视黄酸 致畸作用
2008/1/8
摘要
视黄酸（维甲酸）可引起包括人在内的多种动物胚胎畸形，其生物活性是由一系列视黄酸受体及其配体介导的。其中视黄类受体RAR起主要作用，RAR的配体为强致畸物，相对致畸活性由强至弱依次为配体α、配体β和配体γ。视黄酸受体RXR的配体无致畸活性，但是可加强RAR激动剂的某些致畸郊应。视黄酸受体还可通过其它基因的表达而影响胚胎发育。对视黄类受体基因突变和不同视黄类受体及其配体与致畸作用的关系，以及此...