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Tumor Necrosis Factor-Alpha Polymorphism and Susceptibility to Multiple Sclerosis in the Iranian Population
Tumor Necrosis Factor-Alpha Multiple Sclerosis Sclerosis
2015/10/16
Background: Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Tumor necrosis factor-α (TNF-α) microsatellite as a proinflammatory cytokine is believed to play an important r...
Evolving clinical profile of IL-1β, IL-10 and CTLA-4 gene in rheumatoid factor positive Caucasian population
rheumatoid arthritis Rheumatoid factor Caucasian population CTLA-4
2015/7/22
Rheumatoid arthritis (RA), a systemic autoimmune condition, causes joint damage and sometimes extra-articular lesions (cutaneous vasculitis, neuropathy, Felty’s syndrome, pericarditis, intersticial lu...
Evolving clinical profile of HLA-DRB1,MMP1 and NF-Κb gene in rheumatoid factor positive Caucasian population
Rheumatoid arthritis Rheumatoid factor HLA-DRB1 MMP1 NFkB1
2015/7/22
Rheumatoid arthritis (RA), a systemic autoimmune condition, causes joint damage and sometimes extra-articular lesions (cutaneous vasculitis, neuropathy, Felty’s syndrome, pericarditis, intersticial lu...
LymphTF Database- A Database of Transcription Factor Activity in Lymphocyte Development
LymphTF Database DNA bioinformatics
2015/5/26
Study of the transcriptional regulation of lymphocyte development has advanced greatly in the past 15 years. Owing to improved techniques and intense interest in the topic, a great many interactions b...
Serum response factor-dependent regulation of smooth muscle gene transcription
Smooth muscle cells Gene regulation MicroRNA Chromatin remodeling Serum Response Factor
2015/5/22
Several common diseases such as atherosclerosis, post-angioplasty restenosis, and graft vasculopathies, are associated with the changes in the structure and function of smooth muscle cells. During the...
Is depression a stronger risk factor for cardiovascular disease among individuals with a history of adverse childhood experiences?
Epidemiology cardiovascular disease risk factors inflammation depression cardiovascular
2015/1/9
Epidemiologic studies suggest that depression is an independent risk factor for cardiovascular disease (CVD). Although several possible mediators of this association have been proposed, few studies ha...
The Association of Coagulation Factor V (Leiden) and Factor II (Prothrombin) Mutations With Stroke
Stroke Population Incidence
2015/10/15
Background: Epidemiological studies indicate that over the past forty years, the stroke incidence rates has increased. Factors V and II mutations are established genetic-variant risk factors for venou...
The Effects of Insulin-Like Growth Factor-1 Gene Therapy and Cell Transplantation on Rat Acute Wound Model
IGF-1 Gene Therapy Cell Transplantation Fibroblast Wound Healing
2015/10/15
Background: Wound healing is a complex process. Different types of skin cells, extracellular matrix and variety of growth factors are involved in wound healing. The use of recombinant growth factors i...
A Novel Missense Mutation, E1623G,in the Human Factor VIII Gene Associated With Moderate Haemophilia A
Hemophilia A Mutation Missense F8 protein human
2015/10/10
Introduction:: Haemophilia A is the most common inherited X-linked recessive bleeding disorder. The severity of the resultant bleeding diathesis depends on the FVIII levels associated with the mutatio...
Obsessive-Compulsive Disorder as a Risk Factor in Patients with Implantable Cardioverter Defibrillator
Obsessive-Compulsive Disorder Risk Factor Patients Implantable Cardioverter Defibrillator
2015/9/23
Psychological factors in patients after heart surgery have produced many researches in the past decade.1-4 Most of the past studies have concerned with investigating the effect of depression and anxie...
Interleukin-12 and Tumor Necrosis Factor-Β Gene Polymorphisms as Genetic Susceptibility Factors for Brucellosis in Iranian Patients
Brucella Genetic polymorphisms Interleukin-12 Tumor necrosis factor-β Iran
2015/9/21
cMethods: One hundred and ninety-six patients with brucellosis and 81 healthy farmers (controls) who owned infected animals and consumed their contaminated dairy products were included in this study. ...
Heme Oxigenase 2 Gene Polymorphisms as Genetic Risk Factor in Atherosclerosis in Iranian Patients
Atherosclerosis Heme oxigenase 2 Coronary artery disease Iran
2015/9/21
Background: Heme oxygenase 2 (HMOX2) is an important antioxidative stress enzyme found in the endothelial cells of blood vessels and adventitial nerves. This enzyme in collaboration with heme oxygenas...
Prevalence of Rheumatoid Factor (RF) and Anti-native-DNA Antibodies (anti-n DNA) in Different Age Subpopulations
Rheumatoid factor anti-native-DNA antibodies elderly chronic illness
2009/7/6
In this study, we have evaluated the prevalence of RF and anti-n-DNA in dif-ferent age subpopulations grouped according to their clinical status. RF and anti-n-DNA were measured in the serum of 51 eld...
Administration of Granulocyte Colony Stimulating Factor (G-CSF) in Experimentally Infected Rats
G-CSF E.coli sepsis neutropenia
2009/7/2
We investigated the effect of antibiotic or G-CSF plus antibiotic therapy given to E. coli septic rats. In our study, 80 rats were inoculated transperitoneally with 1 ml of a solution containing 10 7 ...
Effects of Nerve Growth Factor on Acetylcholinesterase Activity of Injured Spinal Cord
Acetylcholinesterase Nerve Growth Factor Spinal Cord Injury
2009/7/2
Fourteen rats were examined and divided into two groups of 7: the control (Group a) and NGF-treated animals (Group B). All animals received a 50 g clip-compression injury to tthe spinal cord at the T9...