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SNAI2蛋白是SNAIL转录因子家族重要的成员之一。最初在胚胎发育的研究中,发现其对关键发育阶段中细胞的形态改变和细胞迁移发挥重要的作用。随后的研究中发现上皮来源的肿瘤细胞只有在上调以SNAI2为代表的转录因子之后,将自己改变为类似成纤维细胞的“窄长”状,并去除细胞之间的粘连,才能获得强大的组织浸润和迁移能力,从而帮助肿瘤细胞实现离开原位组织并最终发生癌症转移。而在病人预后最差的三阴性乳腺癌中,...
Researchers at the University of Illinois report they can alter blood cell development through the use of biomaterials designed to mimic characteristics of the bone marrow.The findings, reported in th...
Study of the transcriptional regulation of lymphocyte development has advanced greatly in the past 15 years. Owing to improved techniques and intense interest in the topic, a great many interactions b...
Immune response enables the body to resist foreign invasions. The Inflammatory response is an important aspect in the immune response which is articulated by elements such as cytokines, APC, T-cell an...
Neural crest cells (NCC) are a multipotent population of cells that form at the dorsal region of neural tube, migrate and contribute to a vast array of embryonic structures, including the majority of ...
Stem cell factor (SCF) mediated c-Kit signaling, and downstream activation of Phosphatidylinositol-3 Kinase (PI-3K) is critical for multiple biological effects mediated by mast cells. Mast cells expre...
The inner ear contains specialized sensory epithelia that detect head movements, gravity and sound. Hearing loss and imbalance are primarily caused by degeneration of the mechanosensitive hair cells i...
We are pleased to announce Cold Spring Harbor Asia conference on Dynamics of Cellular Behavior During Development and Disease which will be held in Suzhou, China, located approximately 60 miles west o...
Background: Localized mast cell accumulation has been reported in a number of human diseases. Suplatast tosilate has been reported to inhibit IL-3-dependent murine mast cell development, and therefore...

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