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A serendipitous finding lends new insight into how atopic dermatitis develops（图）
特应性皮炎 皮肤病 皮肤
2023/7/12
Atopic dermatitis, a common skin condition affecting both children and adults, is often thought of as an inflammatory disease that arises from a breakdown in the barrier function of the skin. Now a ne...
Case Report of Restoration of the Corneal Epithelium in a Patient with Atopic Keratoconjunctivitis Resulting in Amelioration of Ocular Allergic Inflammation
allergic inflammation atopic keratoconjunctivitis conjunctiva corneal ulcer epithelium
2010/11/12
Background: Atopic and vernal keratoconjunctivitis are severe types of ocular allergic disease characterized not only by conjunctival inflammation but also by corneal involvement. In vitro studies hav...
Antitussive Effects of the Leukotriene Receptor Antagonist Montelukast in Patients with Cough Variant Asthma and Atopic Cough
atopic cough cough score cough variant asthma leukotriene receptor antagonist montelukast
2010/11/12
In patients with CVA, 2-week treatment with montelukast, clenbuterol, and montelukast plus clenbuterol all significantly decreased cough scores and treatment with montelukast plus clenbuterol was supe...
Urinary Eosinophil-derived Neurotoxin Concentrations in Patients with Atopic Dermatitis: A Useful Clinical Marker for Disease Activity
atopic dermatitis eosinophil eosinophil-derived neurotoxin visual analogue scale
2010/11/18
Background: It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis.
Methods...
An Improved Mouse Model of Atopic Dermatitis and Suppression of Skin Lesions by an Inhibitor of Tec Family Kinases
allergen atopic dermatitis mite Tec Th2
2010/11/18
We established a highly efficient, highly reproducible protocol to induce skin lesions in NC/Nga mice and successfully applied it to show the efficacy of terreic acid in treating skin lesions. This mo...
Suplatast/Tacrolimus Combination Therapy for Refractory Facial Erythema in Adult Patients with Atopic Dermatitis—A Meta-Analysis Study—
atopic dermatitis erythema meta-analysis suplatast tacrolimus
2010/11/18
Background: Combination of suplatast tosilate with tacrolimus ointment was reported to reduce the dose of tacrolimus ointment with maintained treatment efficacy for refractory facial erythema in atopi...
Effect of Home Environment Control on Children with Atopic or Non-atopic Asthma
asthma Der f 1 Der p 1 environment control house dust mites
2010/11/18
Home visit counseling markedly reduced the frequencies of asthma attacks (p < 0.000001), the required theophylline dosages (p < 0.0005), and the levels of HDM allergens (p < 0.0005) in the atopic subg...
Detection of anti-IgE and anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis
atopic dermatitis auto-antibody high affinity IgE receptor immunoglobulin E
2010/11/25
Anti-IgE and anti-FcεRI α chain auto-antibodies have been detected in the sera of atopic and non-atopic subjects; however, the biological activity of these auto-antibodies is still unclear. These two ...
Eosinophil hypersegmentation is a possible marker to monitor the disease activity of atopic dermatitis
atopic dermatitis eosinophils nuclear lobes of eosinophils
2010/11/25
Background: In the present study, we tried to clarify whether nuclear hypersegmentation of peripheral blood eosinophils is correlated with peripheral eosinophil counts and/or the activity of atopic de...
Evaluation of patch testing in atopic dermatitis using commercially available environmental antigens
atopic dermatitis late phase reaction patch testing
2010/11/25
The patch test positivity rate increased in proportion with the duration of antigen application, with a maximum of 15.6% for mite antigen and a minimum of 4.7% for cedar antigen by 72 h. There were no...
Interleukin-18 is associated with the severity of atopic dermatitis
atopic dermatitis bronchial asthma IgE interferon-γ interleukin-18 interleukin-18 promoter
2010/11/24
The plasma IL-18 level was elevated, particularly in patients with atopic dermatitis. As the clinical severity of atopic dermatitis increased, the plasma IL-18 level also tended to increase. These fin...
Transient shift toward T helper 1 cytokine production by peripheral blood mononuclear cells following successful treatment of patients with atopic dermatitis
atopic dermatitis cytokines interferon-γ interleukin-10 interleukin-12 peripheral blood mono-nuclear cells response to treatment
2010/11/24
Interferon-γ and interleukin (IL)-12 pro-duction increased significantly after 2 weeks treatment (P < 0.005 and P < 0.05, respectively), while IL-10 production decreased significantly after 2 and 4 we...
Two cases of atopic cough successfully treated by oral cleansing with amphotericin B: Relationship with Basidiomycetes detected from pharyngeal swab
amphotericin B (oral cleansing) antifungal drug atopic cough Basidiomycetes pharyngeal swab
2010/11/22
We report herein two cases of atopic cough in which Basidiomycetes was detected from pharyngeal swabs and in which gargling with amphotericin B was efficacious. One case is a 38-year-old woman and the...
Effects of neuropeptides in the development of the atopic dermatitis of mouse models
atopic dermatitis calcitonin gene-related peptide neuropeptides olopatadine hydrochloride substance P
2010/11/22
It is suggested that repeated contact allergic dermatitis or mental stress may promote the development and exacerbation of AD and that substance P has a role in this response. In addition, it seems th...
Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases
atopic dermatitis atopy bronchial asthma Epstein-Barr virus infection
2010/11/22
Anti-EBV, in particular anti-EBNA antibody titer and AtLy count in peripheral blood were markedly higher in patients with bronchial asthma (BA) and/or atopic dermatitis (AD) than in non-atopic control...