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Rac Activation Induces NADPH Oxidase Activity in Transgenic COSphox Cells and Level of Superoxide Production is Exchange Factor-Dependent
NADPH oxidase Rac
2014/12/12
Transient expression of constitutively active Rac1 derivatives, (G12V) or (Q61L), was sufficient to induce phagocyte NADPH oxidase activity in a COS-7 cell model in which human cDNAs for essential oxi...
Serum Transforming Growth Factor-β (TGF-β), Matrix Metalloproteinase-2 (MMP-2), Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitors of Metalloproteinase (TIMP-1) Levels in Childhood Asthma
Asthma children metalloproteinase airway remodelling
2009/6/16
Aims: Airway remodelling is a characteristic feature of asthma and is a dynamic process involving extracellular matrix (ECM) production and its degradation. In this regard, the matrix metalloproteinas...
Age-Related Changes of Transforming Growth Factor β1 in Japanese Children
bronchial asthma single nucleotide polymorphism (SNP) transforming growth factorβ1 (TGFβ1) umbilical cord blood
2010/11/16
Background: Transforming growth factor β1 (TGFβ1) is an important factor in immunomodulation. The expression of TGFβ1 has been shown to be influenced by the C-509T polymorphism in the TGFβ1 gene. We i...