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For a cell to grow and divide, it needs to produce new proteins. This also applies to cancer cells. Researchers have now investigated the protein eIF4A3 and its role in the growth of cancer cells. The...
【本站讯】近日,山东大学齐鲁医院化疗科刘联教授团队的研究成果“N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer” 在Nature 子刊《Cell Death & Disease》杂...
2019年1月21日,生命科学研究院冯新华实验室在Nature Cell Biology (自然•细胞生物学)在线发表了题为“ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumor suppressor functions”的研究论文。该研究首次揭示了在间变性淋巴瘤激酶(ALK)阳性肿瘤中SMAD4存在酪氨酸磷酸化修饰,此...
Cardiovascular disease is the number one cause of death for Americans. New treatments are needed for serious conditions like atherosclerosis, as it can lead to stroke and heart attack. Many types of c...
The response of bSMC migration to bSMC-conditioned medium increased with time in culture, and fibronectin (FIB) was detected as a chemoattractant for bSMCs in bSMC-conditioned medium by western blot a...
There was a significantly increased proportion of IFN-γ-producing and IL-4-producing CD8+ T cells in patients with COPD compared with control subjects (median [IQR] 73.6% [63.9%-80.7%] vs 62.0% [45.6%...
Background: Ag-dependent activation of IgE-bearing mast cells is a critical first step in immediate hypersensitivity and other allergic responses. Recent studies have revealed Ag-independent effects o...
The present study was designed to determine anti-BCG titres, serum albumin, packed cell volume, white blood cell count and malaria parasite density in HIV infected subjects in a malaria endemic area w...
Phenytoin-specific proliferation may be detected with greater sensitivity by the CFSE dilution assay than the conventional LTT. The assay revealed that both CD4+ and CD4- T cells proliferated and prod...
Clinical and histopathological features of basal cell carcinoma (BCC) may differ according to the type of carcinogen involved. BCC arising from radiotherapy treatment has high incidence and its clinic...

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