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Testosterone dose-dependency of sexual and nonsexual behaviors in the gonadotropin-releasing hormone antagonist-treated male rat
Testosterone dose-dependency sexual nonsexual behaviors gonadotropin-releasing hormone male rat
2009/2/23
The testosterone dose-dependency of several mating and nonmating behaviors was examined in the male rat, chemically castrated with a GnRH antagonist analog. Graded doses of testosterone enanthate ...
The effect of long-term opiate antagonist administration to pubertal boys
Puberty opiate control of gonadotropins
2009/2/23
To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15...
Competition of the Histamine H2 Antagonist Cimetidine for Androgen Binding Sites in Man
cimetidine androgen binding prostate testis
2009/2/18
Gynecomastia and impotence have been described as side-effects of cimetidine therapy. It has previously been shown that cimetidine possesses antiandrogenic properties and competes for dihydrotesto...
Effect of acute androgen withdrawal by GnRH antagonist on epididymal sperm motility and morphology in the cynomolgus monkey
acute androgen withdrawal GnRH epididymal sperm motility
2009/2/18
Hormonal male contraception requires an induction phase before azoospermia and contraceptive safety are achieved. The nature of spermatozoa that may be ejaculated during this induction phase was s...
Comparative effects of two different delivery systems on gonadotropin-releasing hormone(GnRH) antagonist-induced suppression of gonadotropins and testosterone in man
GnRH antagonists luteinizing hormone (LH)
2009/2/12
The Nal-Glu gonadotropin-releasing hormone (GnRH) antagonist, when given in daily subcutaneous (SC) doses of 5 mg or higher, maximally suppresses serum luteinizing hormone (LH) and follicle-stimul...
Treatment of idiopathic erectile dysfunction in men with the opiate antagonist naltrexone--a double-blind study
Naltrexone idiopathic erectile dysfunction doubleblind
2009/2/12
Opiate antagonists can indirectly stimulate the secretion of luteinizing hormone (LH) and testosterone, as well as sexual functions in animals and humans. We therefore treated 20 otherwise healthy m...
Recovery of pituitary-gonadal function in male rats after long-term suppression induced by a single injection of microcapsules of LH-RH antagonist cetrorelix(SB-75)
Reversible gonadal inhibition cancer contraception
2009/2/12
The clinical utility of luteinizing hormone-releasing hormone (LH-RH) analogs can be greatly enhanced by a sustained delivery system, which could maintain elevated peptide levels in the blood for ...
Negative feedback regulation of pulsatile LH secretion during treatment with an LHRH antagonist in rams
LHRH antagonists steriod feedback hypothalamus pituitary gland testis testosterone
2009/2/6
Suppression of LH and testosterone secretion in sexually active rams by the short-term administration of an LHRH antagonist results in a compensatory increase in the release of LHRH from the hypot...
Gonadotropin-Releasing Hormone Antagonist (Cetrorelix) Therapy Fails to Protect Nonhuman Primates(Macaca arctoides)From Radiation-Induced Spermatogenic Failure
Macaque testis spermatogenesis
2008/12/23
Treatment of men of reproductive age with radiation or alkylating agents often produces prolonged azoospermia. We previously demonstrated that suppression of testosterone (T) with gonadotropin-rel...
Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction
Pilot study endothelin-A receptor treatment erectile dysfunction
2008/12/1
Endothelins have been postulated to be important regulators of penile erectile function. The endothelin-A receptor antagonist BMS-193884 was evaluated as a treatment for mild-to-moderate erectile dysf...
Gonadotrophin releasing hormone antagonist in IVF/ICSI
Assisted reproduction Gonadotrophin releasing hormone antagonists ICSI IVF
2008/11/13
Objective : To study the efficacy of gonadotrophin releasing hormone (GnRH) antagonist in In-vitro-fertilization/Intracytoplasmic sperm injection (IVF/ICSI) cycles. Type of Study : Observational study...