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Testosterone dose-dependency of sexual and nonsexual behaviors in the gonadotropin-releasing hormone antagonist-treated male rat
Testosterone dose-dependency sexual nonsexual behaviors gonadotropin-releasing hormone male rat
2009/2/23
The testosterone dose-dependency of several mating and nonmating behaviors was examined in the male rat, chemically castrated with a GnRH antagonist analog. Graded doses of testosterone enanthate ...
Heterogeneity of sperm density profiles following 16-week therapy with continuous infusion of high-dose LHRH analog plus testosterone
sperm density profiles 16-week therapy high-dose LHRH testosterone
2009/2/23
LHRH agonist analogs have been investigated as potential male contraceptives. It has been shown that the LHRH agonistic analog [D-Trp6,Pro9-NEt] LHRH (LHRHA) given to men in single doses up to 500 m...
Dose and time relationships in the endocrine response of the irradiated adult rat testis
endocrine response irradiated adult rat testis
2009/2/23
The dose- and time-dependent responses for the interstitial and tubular compartments in irradiated adult rat testes are described. Leydig cell dysfunction, as indicated by increased serum LH (to a m...
Dose-response studies on male reproductive parameters in dogs with nafarelin acetate, a potent LHRH agonist
LHRH agonist nafarelin acetate EDNal(2)6JLHRH spermatogenesis prostate male dogs
2009/2/20
Adult male beagle dogs were administered daily subcutaneous injections of either 0.5 or 2.0 micrograms/kg of a potent LHRH agonist, nafarelin acetate, for 44 days. Although there was a rise in the c...
Heterogeneity of sperm density profiles following 20-week therapy with high-dose LHRH analog plus testosterone
LHRH analog sperm density heterogeneous response
2009/2/20
Eight normal male volunteers received an LHRH analog, 100 to 500 micrograms daily, for 20 weeks. Testosterone enanthate, 100 mg, was given by injection every second week. Sperm density fell to 5.5 X...
Effects of Chronic, High-dose LHRH-Agonist Treatment on Pituitary and Testicular Functions in Rhesus Monkeys
Chronic High-dose LHRH-Agonist Treatment Pituitary Testicular Functions Rhesus Monkeys
2009/2/18
The effects of chronic, high-dose treatment with an LHRH-agonist (D-Ser-(TBu)6-LHRH-ethylamide) on pituitary and testicular functions were investigated in four adult rhesus monkeys in-season. Doses ...
Estradiol and high-dose dihydrotestosterone treatment causes changes in cynomolgus monkey prostate volume and histology identical to those caused by testosterone alone
Male transrectal ultrasonography androgens estrogens
2009/2/18
To evaluate the effects of testosterone (T), dihydrotestosterone (DHT), and estradiol (E2) on the regulation of prostate growth and tissue composition, the following study was conducted in a nonhuma...
Spermatic granulomata are experimentally induced in epididymides of mice receiving high-dose testosterone implants. I. A light-microscopical study
Spermatic granulomata high-dose testosterone
2009/2/18
It is known that a spermatic granuloma is induced by the inflammatory reaction following leakage of spermatozoa outside the germ cell ducts and is the main clinical complication of vasectomy. In t...
Effect of low-dose testicular irradiation on sperm count and fertility in patients with testicular seminoma
Testicular cancer radiation treatment sperm banking
2009/2/13
The treatment of seminoma with radiation therapy risks transient infertility. We have prospectively followed eight patients with stage I seminoma of the testicle. All patients underwent radical or...
Pharmacokinetics and pharmacodynamics of a parenteral testosterone microsphere formulation in the male rat. Demonstration of dose dependence and controlled release
Testosterone microsphere formulation androgen delivery methods testosterone effects on LH, FSH, and accessory sex organs rat
2009/2/11
This study examined the pharmacokinetics (the time course and pattern of testosterone release) and pharmacodynamics (effects on accessory sex organ weights, and serum LH and FSH levels) of a biode...
Dose-response effects of gonadotropin-releasing hormone on plasma concentrations of gonadotropins and testosterone in fertile and subfertile stallions
gonadotropin-releasing hormone luteinizing hormone follicle-stimulating hormone testosterone horse fertility
2009/2/11
Five fertile and five subfertile stallions were treated with a single intravenous injection of saline the first week followed by a single intravenous injection of varying doses of gonadotropin-rel...
Acute and long-term effects of a single dose of the fungicide carbendazim（methyl 2-benzimidazole carbamate）on the male reproductive system in the rat
fungicide carbendazim（methyl 2-benzimidazole carbamate） male reproductive system rat
2009/2/11
The effects of carbendazim (methyl 2-benzimidazole carbamate) on the testis, efferent ductules, and sperm were determined in the adult rat after a single oral dose. Two experimental trials were perf...
Dose–Response Relationship Between Testosterone and Erectile Function: Evidence for the Existence of a Critical Threshold
Androgens erection neural NOS phosphodiesterase type 5 prostate
2008/12/24
Androgens play an important role in erectile function. However, the dose–response relationship between plasma testosterone levels and penile erection remains unclear. Intact (sham operated) or bi...
Permanent Induction of Morphological Abnormalities in the Penis and Penile Skeletal Muscles in Adult Rats Treated Neonatally With Diethylstilbestrol or Estradiol Valerate：A Dose-Response Study
Estrogen DES fertility testosterone bulbocavernosus
2008/12/22
This study evaluated the effects of neonatal exposure to different doses of diethylstilbestrol (DES) or estradiol valerate (EV) on penile morphology, penile skeletal muscles, and fertility. Male pup...
Pharmacokinetics and Degree of Aromatization Rather Than Total Dose of Different Preparations Determine the Effects of Testosterone：A Nonhuman Primate Study in Macaca fascicularis
Spermatogenesis testis male contraception clinical chemistry primates
2008/12/19
Currently available testosterone (T) preparations differ substantially in their pharmacokinetic profile that might influence their androgenic properties in terms of suppression of the gonadal axis, ef...