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Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors（图）
癌细胞 选择性加载 T细胞 浸润肿瘤
2023/7/7
Checkpoint inhibitor drugs have been a gamechanger for many cancer patients. Yet around 70% don’t respond to these medications, which work by removing the “brakes” on the immune system’s response to a...
Disparate functions of myeloid-derived suppressor cells in cancer metastasis
Disparate functions cancer metastasis
2015/4/14
Myeloid-derived suppressor cells comprise a heterogeneous population of immature immune cells that expand during the course of cancer progression. These cells adopt an immunosuppressive phenotype that...
APPLICATION OF GENETICALLY ENGINEERED TUMOR-SPECIFIC TH1 CELLS TO ADOPTIVE TUMOR IMMUNOTHERAPY
Carcinoembryonic antigen chimeric immunoglobulin T cell receptor DO11.10 gene transfer immunotherapy
2009/7/15
CD4+ Th cells, in particular IFN-γ-producing Th1 cells, play a critical role in the activation and maintenance of CD8+ Tc1 cells that are essential for tumor eradication. Recent identification of MHC ...