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Bayesian法预测丙戊酸药动学参数及个体化给药方案的研究
丙戊酸 药动学 参数个体化 给药方案
2008/12/2
该项目的应用领域为临床药学。开展荧光偏振免疫法(FPIA)测定癫痫患者丙戊酸血药浓度和超滤法测定游离丙戊酸血药浓度及其蛋白结合率；用Bayesian法估算个体药动学参数，制定/优化个体化给药方案。采用Bayesian法结合群体药动学参数和患者个体特征信息，用一个时间-血药浓度点数据一步估算患者丙戊酸药动学参数的研究，国内只在近2年内有少量报道，游离丙戊酸血药浓度及蛋白结合率测定在国内22年文献...
Development and Application of an On-line Module for Teaching Bayesian Forecasting Principles in a Clinical Pharmacokinetics Course
Teaching Bayesian Forecasting Principles Clinical Pharmacokinetics Course
2016/3/15
A web-based module is developed as a learning tool for pharmacokinetic parameter estimation based on non-linear regression analysis and Bayesian principles. After entering the data related to dosage r...