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The work by a research team made up largely of Brown graduate and undergraduate students addresses a critical biomedical need and has the potential to be widely adapted by clinicians to monitor antide...
The majority of bacterial infections involve the formation of biofilms. Biofilm formation is nutrient and growth dependent. Determination of the effects of nutrients on exopolysaccharide production an...
Aim: To present a case of hamartoma of the optic disc and Retinal Pigment Epithelium (RPE) and follow up of the visual function over three-years period. Methods: A seventeen-year-old boy has observed ...
Confocal microscopy is frequently used to examine the subcellular distributions of proteins or otherbiological macromolecules, but essentially all interpretation of the patterns in the resulting image...
Immunofluorescence microscopy is widely used to analyze the subcellular locations of proteins, but current approaches relyon visual interpretation of the resulting patterns. To facilitate more rapid, ...
Automated Interpretation of Protein Subcellular Location Patterns: Implications for Early Cancer Detection and Assessment.
Background: Detailed knowledge of the subcellular location of each expressed protein is critical to a fullunderstanding of its function. Fluorescence microscopy, in combination with methods for fluore...
Fluorescence microscope images capture information from an entire field of view, which often comprises several cells scattered on the slide. We have previously trained classifiers to accurately pre...
Fluorescence microscopy is widely used to analyze the distribution of proteins within cells. As currently practiced, the assignment of a protein to a particular organelle is done by visual inspecti...
Knowing the subcellular location of a protein is critical to a full understanding of its function, and automated, objective methods for assigning locations are needed as part of the characterizatio...
We describe the Protein Subcellular Location Image Database (PSLID), which collects and structures 2-D through 5-D fluorescence microscope images, annotations, and derived features in a relational ...
Determination of the functions of all expressed proteins represents one of the major upcoming challenges in computational molecular biology. Since subcellular location plays a crucial role in prote...
The widespread proliferation of automated fluorescence-microscope systems has made the acquisition of digital images commonplace in cell-biology research. This has created a need for computer app...
Methods for numerical description and subsequent classification of cellular protein localization patterns are described. Images representing the localization patterns of 4 proteins and DNA were ob...
The early signs of diabetic retinopathy (DR) are depicted by microaneurysms among other signs. A prompt diagnosis when the disease is at the early stage can help prevent irreversible damages to the di...

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