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Matrix metalloproteinases (MMPs) are known to play a critical role in tissue disintegration, and an elevated level of MMPs is observed in synovium and synovial fluid of joints with rheumatoid arthriti...
白细胞介素33(interleukin-33,IL-33)作为IL-1细胞因子家族的一个新成员,可以通过作用肥大细胞或Th2型细胞而发挥生物学功能。IL-33能诱导T细胞向Th2方向分化,激活肥大细胞、树突状细胞、嗜酸性粒细胞和嗜碱性粒细胞,增加相应细胞因子的表达,从而在机体的炎症性疾病和寄生虫感染造成的病理损伤中发挥重要作用。该文对IL-33作用的靶细胞及其在寄生虫感染免疫中的作用进行综述。
Although the efficacy of tuberculosis (TB) vaccines is tightly linked to cell-mediated immunity, some functions of T and B cells in TB patients remain unclear. To address how Mycobacterium tuberculosi...
Objective Tripterygium wilfordii Hook.f.has been used for centuries in traditional Chinese medicine to treat autoimmune disease associated with increased production of the proinflammatory cytokine.Tr...
Immunobiological roles of schistosome eggs during murine experimental infection were investigated with special reference to the induction of basophilic leukocytes. After single- or bisexual infection ...
We established models of cancer-related anemia in mice from subcutaneous inoculation of two IL-6-producing cancer cell lines, human lung cancer cell line LC-06-JCK and murine colon26 clone 5 colon c...
It has been well recognized that TGF-β is able to induce CD4+CD25+Foxp3+ suppressor/regulatory T (iTreg) cells and IL-2 facilitates iTreg induction and expansion, however, only half of TGF-β-induced C...
Plasminogen activator (PA) is the enzyme that converts plasminogen to its active form, plasmin, which is involved in various physiological and pathological phenomena. The conversion is catalyzed by ...

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