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Multiple testing of local maxima for detection of peaks in ChIP-Seq data
False discovery rate kernel smoothing matched filter Poisson sequence topological inference
2013/6/14
A topological multiple testing approach to peak detection is proposed for the problem of detecting transcription factor binding sites in ChIP-Seq data. After kernel smoothing of the tag counts over th...
Sequential testing over multiple stages and performance analysis of data fusion
Sequential testing over multiple stages performance analysis data fusion
2013/4/28
We describe a methodology for modeling the performance of decision-level data fusion between different sensor configurations, implemented as part of the JIEDDO Analytic Decision Engine (JADE). We firs...
Testing composite hypotheses, Hermite polynomials and optimal estimation of a nonsmooth functional
Best polynomial approximation ℓ 1 norm composite hypothe-ses Hermite polynomial minimax lower bound nonsmooth functional optimal rate of convergence
2011/6/17
A general lower bound is developed for the minimax risk when
estimating an arbitrary functional. The bound is based on testing
two composite hypotheses and is shown to be effective in estimating
th...