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Successful response to imatinib in two dogs with inoperable grade III infiltrating mast cell tumours:a case report
canine KIT oncogene target therapy tyrosine kinase inhibitor
2016/9/1
Two dogs were presented owing to sudden rapid growth of cutaneous masses greater than 10 cm on the neck and axillary region, respectively. Based on history and results of physical examinations, blood ...
DIFFERENTIAL ROLE OF PI-3KINASE p85 (α & β) REGULATORY SUBUNITS IN MAST CELL DEVELOPMENT
Cell cycle -- Regulation Enzymes
2015/5/25
Stem cell factor (SCF) mediated c-Kit signaling, and downstream activation of Phosphatidylinositol-3 Kinase (PI-3K) is critical for multiple biological effects mediated by mast cells. Mast cells expre...
ERK1 AND ERK2 IN HEMATOPOIESIS, MAST CELL FUNCTION, AND THE MANAGEMENT OF NF1-ASSOCIATED LEUKEMIA AND TUMORS
hematopoiesis neurofibroma leukemia
2015/5/25
Neurofibromatosis type 1 is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene, which encodes a protein serving, at least in part, to acce...
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
mast cells Pak1 allergic diseasis
2014/12/12
Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators. The biochemical pathways linking IgE...
Canine Cutaneous Mast Cell Tumor: Biologic Behavior and Its Correlation with Prognostic Indicators
Sabrina dos Santos Costa Poggiani Erika Maria Terra
2013/2/19
Cutaneous mast cell tumor (MCT) shows a variable biological behavior in dogs and may present either as solitary masse that can be treated and cured with surgical removal or as a systemic metastatic an...
Evaluation of Collection and Distribution of Samples for Histological, Stereological Analysis and Cell Culture of Canine Mast Cell Tumors
Mast Cell Tumor Oncologic Surgery Canine Tumor Collection Stereological Analysis
2013/2/19
Objective: To collect high quality, representative tissue material from tumors and manage its distribution to different laboratories. Design: Prospective controlled study. Animals: Thirty-six dogs wit...
Effect of Pentoxifylline Administration on Mast Cell Numbers and Degranulation in a Diabetic and Normoglycemic rat Model Wound Healing
Pentoxifylline Mast cells Diabetes Mellitus Wound Healing
2015/9/28
Background: Wound healing is a complicated and integrated process. Researches in the molecular level on human and animal models have indicated several molecular changes related to the effect of diabet...
Evaluation of CD31 Expression and Mast Cell Count in Dysplastic Lesions and Squamous Cell Carcinoma of the Oral Cavity
SCC CD31 Mast cell Oral cavity
2015/9/21
Background: Squamous cell carcinoma (SCC) is the most common malignancy in the oral cavity. Angiogenesis is essential for development and progression of SCC. Recently, some studies have reported that ...
Polyclonal IgE Induces Mast Cell Survival and Cytokine Production
allergy antibodies cell activation human mast cells/basophils
2010/11/16
Background: Ag-dependent activation of IgE-bearing mast cells is a critical first step in immediate hypersensitivity and other allergic responses. Recent studies have revealed Ag-independent effects o...
Gene Expression Profiling of Human Mast Cell Subtypes: An In Silico Study
carboxypeptidase chymase human mast cells microarray transcriptome
2010/11/18
The MC lineage seems to be far from the granulocyte lineages including basophils. CMA1-high MCs (MCTC) and CMA1-low MCs (MCT) can be regarded as differentiated MC subtypes. As such, importance of data...
Stimulatory effect of cytochalasin D on antigen-induced phospholipase D activation in a murine mast cell model (RBL-2H3)
cytochalasin intracellular signal transduction mast cells phospholipase D
2010/11/29
To investigate the possible involvement of cytoskeletal components in antigen (Ag)-mediated activation of phospholipase D (PLD) in rat basophilic leukemia (RBL-2H3) cells, the effects of cytochalasin ...
Mast cell function modulating IgE-mediated allergy
allergy FcεRI local IgE synthesis mast cell
2010/11/29
Allergic diseases, such as atopic rhinitis, bronchial asthma and urticaria, are prevalent and increasing in frequency. Mast cells are known to play a central role in the immediate phase reaction of al...
Differences in mast cell-bound IgE in the nasal epithelial layer and lamina propria
allergic rhinitis IgE immunohistochemistry mast cell nasal mucosa
2010/11/25
Mast cells in the allergic nasal mucosa are reported to have higher concentrations of high affinity type I Fcε receptors (FcεRI) than mast cells in the non-allergic mucosa. IgE binds to FcεRI on mast ...
Role of protein kinase A in the inhibition of human mast cell histamine release by β-adrenergic receptor agonists
β-adrenergic receptor agonist histamine release human cultured mast cells protein kinase A protein kinase C
2010/11/24
Stimulation of mast cells induced the elevation of intracellular cytosolic free Ca2+ concentrations ([Ca2+]i) and the translocation of protein kinase C (PKC) from the cytosol to the cell membrane, fol...
Human mast cell activation through Fc receptors and Toll-like receptors
adaptive immunity FcεRI FcγRI GeneChip innate immunity mast cell Toll-like receptor 4
2010/11/22
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE. Recent studie...