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Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...
Vitamin D deficiency in Europe: pandemic?
vitamin D deficiency prevalence 25(OH)D standardized Europe
2018/11/28
Background: Vitamin D deficiency has been described as being pandemic, but serum 25-hydroxyvitamin D [25(OH)D] distribution data for the European Union are of very variable quality. The NIH-led intern...
Medicago truncatula ecotypes A17 and R108 differed in their response to iron deficiency
Medicago truncatula Ecotype A17 Ecotype R108 Fe deficiency Ferric chelate reductase activity
2015/2/5
Medicago truncatula Gaertn is a model legume species with a wide genetic diversity. To evaluate the responses of the two M. truncatula ecotypes, the effect of Fe deficiency on ecotype A17 and ecotype ...
Brassi nosteroids are involved in response of cucum ber ( Cuc umis sativus) to iron deficiency
Brassinosteroids iron deficiency cucumber Cucumis sativus ferric reductase activity Fe translocation
2015/2/5
Background and Aims Brassinosteroids (BR) are a class of plant polyhydroxysteroids with diverse functions in plant growth and development. However, there is little information on the role of BRs playe...
Stimulation of root acid phosphatase by phosphorus deficiency is regulated by ethylene in Medicago falcata
Phosphorus deficiency Ethylene Medicago falcata Acid phosphatase activity Phosphate transporters Organic phosphorus
2015/2/5
Plants have developed numerous strategies to cope with phosphorus (P) deficiency resulting from low availability in soils. Evolution of ethylene and up-regulation of root secreted acid phosphatase act...
Nitric oxide is involved in phosphorus deficiency-induced cluster-root development and citrate exudation in white lupin
citrate exudation cluster roots nitric oxide phosphorus deficiency white lupin (Lupinus albus)
2015/2/5
White lupin (Lupinus albus) forms specialized cluster roots characterized by exudation of organic anions under phosphorus (P) deficiency. Here, the role of nitric oxide (NO) in P deficiency-induced cl...
Phosphorus deficiency-induced reduction in root hydraulic conductivity in Medicago falcata is associated with ethylene production
Phosphorus deficiency Root hydraulic conductivity Ethylene production Aquaporins Medicago falcata L
2015/2/5
Plants grown in phosphorus-deficient solutions often exhibit disruption of water transport due to reduction in root hydraulic conductivity (Lpr) and enhanced ethylene production. To uncover the relati...
Citrate exudation from white lupin induced by phosphorus deficiency differs from that induced by aluminum
aluminum citrate exudation cluster root phosphorus deficiency white lupin (Lupinus albus)
2015/2/5
Both phosphorus (P) deficiency and aluminum (Al) toxicity induce root exudation of carboxylates, but the relationship between these two effects is not fully understood.Here, carboxylate exudation indu...
High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice
choline metabolism folic acid lipid metabolism liver methylenetetrahydrofolate reductase
2018/12/24
Background: Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are larg...
Stoichiometric imbalance in rates of nitrogen and phosphorus retention, storage, and recycling can perpetuate nitrogen deficiency in highly-productive reservoirs
nitrogen phosphorus retention storage
2014/11/28
We measured the nutrient stoichiometry of inputs, outputs, retention, storage, and recycling in three seasonally
nitrogen (N)-deficient reservoirs by incorporating watershed mass balances with measur...
On Titchmarsh-Weyl functions of first-order symmetric systems with arbitrary deficiency indices
First-order symmetric system decomposing boundary triplet Nevanlinna boundary conditions m-function
2012/6/19
We study general (not necessarily Hamiltonian) first-order symmetric systems $J y'(t)-B(t)y(t)=\D(t) f(t)$ on an interval $[a,b> $ with the regular endpoint $a$. The deficiency indices $n_\pm$ of the ...
Association Between Geophagia and Haematological Parameters of Iron Deficiency Anaemia in Geophagic Qwa-Qwa Women
Association Between Geophagia and Haematological Parameters of Iron Deficiency Anaemia in Geophagic Qwa-Qwa Women
2012/3/14
Association Between Geophagia and Haematological Parameters of Iron Deficiency Anaemia in Geophagic Qwa-Qwa Women.
ACQUIRED STAT4 DEFICIENCY AS A CONSEQUENCE OF CANCER CHEMOTHERAPY
STAT4 Lymphoma Chemotherapy
2015/5/22
Signal Transducer and Activator of Transcription 4 (STAT4) is an important transcription factor activated by IL-12 signaling. Activated STAT4 is essential for Th1 cell differentiation, a process chara...
Critical partitions and nodal deficiency of billiard eigenfunctions
Critical partitions nodal deficiency billiard eigenfunctions Mathematical Physics
2011/9/14
Abstract: The paper addresses the the number of nodal domains for eigenfunctions of Schr\"{o}dinger operators with Dirichlet boundary conditions in bounded domains. In dimension one, the $n$th eigenfu...
SIRT1 DEFICIENCY COMPROMISES MOUSE EMBRYONIC STEM CELL DIFFERENTIATION, AND EMBRYONIC AND ADULT HEMATOPOIESIS IN THE MOUSE
Mouse Embryonic Stem Cell Hematopoietic Cell Differentiation
2015/5/21
SIRT1 (Sirtuin 1) is a founding member of a family of seven proteins and histone deacetylases. It is involved in cellular resistance to stress, metabolism, differentiation, aging, and tumor suppressio...