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Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
Fusion mechanism 2019-nCoV inhibitors targeting HR1 domain spike protein
2020/6/12
Very recently, a novel coronavirus, 2019-nCoV, emerged in Wuhan, China and then quickly spread worldwide, resulting in >17,388 confirmed cases and 361 deaths as of 3 February 2020, thus calling for th...
Mechanism for the increase in plasma triacylglycerol concentrations after consumption of short-term, high-carbohydrate diets
Stable isotopes fatty acid liver
2016/6/13
High-carbohydrate (HC) diets are recommended
for lowering the risk of coronary heart disease because they
decrease plasma LDL-cholesterol concentrations. However, an
unfavorable effect of HC diets ...
Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
tissue transglutaminase TGF-beta ovarian cancer
2015/5/25
Ovarian cancer (OC) is a lethal disease due to metastasis and chemoresistance. Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal m...
ENDURANCE TRAINING AND GLUTATHIONE-DEPENDENT ANTIOXIDANT DEFENSE MECHANISM IN HEART OF THE DIABETIC RATS
Streptozotocin experimental diabetes mellitus glutathione
2015/3/11
Regular physical exercise beneficially influences cardiac antioxidant defenses in normal rats. The aim of
this study was to test whether endurance training can strengthen glutathione-dependent antio...
Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties
mechanical testing raloxifene toughness water bone loss
2014/12/4
Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties,...
Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties
Raloxifene mechanicaltesting toughness water
2014/11/6
Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties,...
In the triathlon the combined practice of swimming, cycling and running permits the reduction of overuse injuries compared to the practice of the running alone. Redistribution of stress over several p...
ECG in sinus rhythm with ventricular preexcitation and changing QRS morphology was seen that was initially interpreted as the multiple accessory pathway from elsewhere. (Figure 1A). The following mech...
Effect of Tindurin on Immunopathogenesis Mechanism of Collagen-Induced Arthritis
Anti-malarial drugs Tindurin
2009/12/30
Rheumatoid arthritis is a chronic inflammatory disease characterized by the sequestration of various leukocyte subpopulations within both the developing pannus and synovial space. This study was under...
GENETICS AND MECHANISM OF MALATHION RESISTANCE IN ANOPHELES STEPHENSI FROM BANDAR-ABBAS AND ITS CROSS RESISTANCE SPECTRUM TO DDT,DIELDRIN AND PIRIMIPHOS-METHYL
Synergiat Cross and Back-Cross
2009/12/30
The genetics and mechanism of malathion resistance in the adults of An. stephensi (BAN-S), Was studied. Nine successive generations of malathion selection in the adults resulted in an increase in LTSO...
Kinetic mechanism reduction based on an integer programming approach
Kinetic mechanism reduction an integer programming approach
2009/12/24
Kinetic mechanism reduction based on an integer programming approach.
Arterial gas embolism as a pathophysiologic mechanism for spinal cord decompression sickness
decompression Arterial gas embolism spinal cord animal dog
2009/7/9
A continuous infusion of air (1.0 ml.min-1) was delivered via a fine aortic cannula into the arterial circulation of 7 anesthetized dogs until no spinal cord function could be elicited by somatosensor...
The Change of Glutathione Dependent Anti-Oxidant Mechanism in Patients with Chronic Renal Disease by Hemodialysis
Glutathione Glutathione peroxidase Glucose 6-Phosphate dehydrogenase Hemodialysis
2009/7/6
In order to test the for existence of a possible effect during hemodialysis we investigated glutathione and related enzymes before and after dialysis of 36 patients (20 M/16 F) with chronic renal fail...
Alterations of Erythrocyte and Plasma Lipid Peroxides as well as Antioxidant Mechanism in Patients with Type II Diabetes Mellitus (NIDDM)
Lipid peroxidation Superoxide dismutase catalase glutathione
2009/7/3
It has been maintained that free oxygen radicals (FOR) that occur in cell have important roles in the ethiopathogenesis of diabet, and that cell damage progressing as a result of their accumulation is...
The Role of Renin-Angiotensin System in Regulating Fibrinolytic Balance:Potential Mechanism in Prevention of Myocardial Infarction
Renin angiotensin myocardial infarction fibrinolysis
2009/6/30
Over the last two decades, there has been an impressive growth of experimental and clinical evidence defining a role for the renin-angiotensin system (RAS) in the development of ischemic cardiovascul...