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2024年6月13日，北京大学基础医学院、北京大学感染病研究中心鲁凤民/陈香梅研究团队在JHEP Reports杂志在线发表题为“Hepatitis B virus enhancer 1 activates preS1 and preS2 promoters of integrated HBV DNA impairing HBsAg secretion”的研究，该研究阐明了整合HBV DNA来源H...
Hippo信号通路在肿瘤发生发展中发挥重要作用，其效应蛋白YAP/TAZ转录辅助因子在多种肿瘤中显著激活[1, 2]。因此，靶向Hippo通路的肿瘤治疗策略具有很好的临床转化前景。然而，目前尚无相关药物真正进入临床用于肿瘤治疗[3]。近年来，基于抗体和细胞的靶向疗法方兴未艾，如果能鉴定出一种体现Hippo通路活性的细胞表面标志物，将为靶向Hippo通路的肿瘤治疗带来全新可能性。
基因组每时每刻都遭受着来自内外源各种因素引起的DNA损伤。机体通过不同的DNA修复机制来纠正和修复损伤，维持基因组稳定性。碱基切除修复（BER）是机体维持基因组稳定的一线修复途径，可以有效地修复多种DNA损伤类型，包括各种DNA碱基损伤和单链断裂。作为细胞抵抗损伤的主要防御手段，BER过程的失调或功能障碍与多种疾病密切相关，包括神经退行性疾病、衰老、肿瘤和化疗抵抗等。尽管BER的各个步骤已经基本清...
2022年6月14日，上海交通大学医学院上海市免疫学研究所吴学锋课题组等在国际学术期刊Cell Reports在线发表题为 “Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation” 的研究论文，研究...
自身免疫性疾病通常被认为是既是器官特异性又是全身性的疾病，其发生主要是由于免疫系统出现故障，误攻击了自身的细胞和组织，全世界大约有8%-10%的人口受到自身免疫性疾病的影响。尽管现有的治疗方法(如小分子和抗体药物)有助于减缓疾病进展及减少残疾的发生，但均存在较严重的副作用，且无法真正逆转疾病的表现。因此，寻找新的创新治疗方法和药物分子是目前转化医学研究的首要目标。
Gaskins et al. study reports on a new opportunity for breast cancer prevention
gut microbiome research beneficial gut microbiota epidemiologic study
2018/11/16
Gaskins et al. (1) reports on a promising new opportunity for gut microbiome research. Dietary manipulations to promote the growth of beneficial gut microbiota are currently being investigated as a no...
Malignant Melanoma of Nose and Paranasal Sinuses: 2 Case Reports
Malignant Melanoma Nose Paranasal sinuses
2015/7/16
Malignant melanoma is one of the rare and highly aggressive diseases of the sinonasal cavity. High index of suspicion is required for diagnosis as the patient usually presents with non specific signs ...
Reports of Child Abuse in India from Scientific Journals and Newspapers-An Exploratory Study
Child Abuse Journals Newspapers India
2015/6/10
Background: Child abuse is a state of emotional, physical, economic and sexual maltreatment meted out to a person below the age of eighteen and is a globally prevalent phenomenon. A total of 33,098 ca...
Evaluating the Variation on Public Health’s Perceived Field Need of Communicable Disease Reports
communicable disease reports
2015/3/5
Evaluating the Variation on Public Health’s Perceived Field Need of Communicable Disease Reports.
Evaluating the Variation on Public Health’s Perceived Field Need of Communicable Disease Reports
Evaluating the Variation Communicable Disease Reports
2014/11/19
To assess communicable disease report fields required by public
health practitioners and evaluate the variation in the perceived utility
of these fields.p
Adaptation of the CARE Guidelines for Therapeutic Massage and Bodywork Publications: Efforts To Improve the Impact of Case Reports
case study massage therapy manual therapy evidenced-based practice
2014/11/14
Case reports provide the foundation of practice-based evidence for therapeutic massage and bodywork (TMB), as well as many other health-related fields. To improve the consistency of information contai...
Case Reports: A Meaningful Way for Massage Practice to Inform Research and Education
scientifi writing help negative results practice informing research practice informing education
2014/11/14
Practice-induced challenges to massage research and education include those related to disparate training standards, requirements, and expectations across the US, North America, and internationally. T...
Repeated Resection for Pulmonary Metastatic Hepatocellular Carcinoma after Liver Transplantation— Case Reports and a Proposal of Negative Predictors for the Recurrence after the Operation
Hepatocellular Carcinoma Liver Transplantation Recurrence Lung
2013/2/19
Background: Orthotropic liver transplantation (OLTx) is recognized as a radical therapy for unresectable hepatocellular carcinoma (HCC) without distant metastasis. Although the outcome depends on dist...
Differentiation and diagnosis of migrating cerebral sparganosis: 2 case reports from China
Chinese Spirometra Sparganosis Cerebral Sparganosis
2013/1/29
Human cerebral sparganosis is a rare but neglected parasitic disease. We present details of the diagnosis of two cases of migrating cerebral sparganosis from China based on computed tomography and mag...
Infections: The Achilles Heel of Immunosuppression for Renal Transplantation and Immunological Renal Disease Management in the Top End of Northern Australia: Case Reports
Renal Transplant Immunological renal disease Lupus Nephritis
2013/1/31
Improved immunosuppression regimens have led to better survival for patients with renal transplant grafts and patients with immunological renal diseases worldwide. However, this is not the case in the...