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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
Osteoprogenitor Estrogen depletion
2015/5/21
We have shown that nuclear matrix protein 4 (Nmp4) attenuates the response to intermittent parathyroid hormone (PTH) in healthy and ovariectomized (OVX) female mice using a global knockout of the Nmp4...
Molecular Mechanisms of FLT3-ITD-Induced Leukemogenesis
Acute myeloid leukemia Blood -- Diseases
2015/5/21
Internal tandem duplications in FMS-like receptor tyrosine kinase (FLT3-ITDs) are seen in approximately 25% of all acute myeloid leukemia (AML) patients. FLT3-ITDs induce FLT3 ligand (FL)-independent ...
Chemoprevention of MNU and Testosterone induced prostate carcinogenesis by Calcitriol (vitamin D3) in adult male albino Wistar rats
Calcitriol Chemoprevention Methyl nitroso urea Prostate cancer Prostatic intraepithelial neoplasia
2009/7/15
Background Calcitriol is a steroid hormone, inhibits the proliferation and promotes the differentiation of human prostate cancer cells. Calcitriol markedly inhibits the invasiveness of human prostate ...
Hyperthermic sensitizers targeting heat-induced signal transductions
hyperthermic sensitivity heat apoptosis inhibitor sensitizer
2009/7/15
Hyperthermia has been used as one of the efficacious cancer therapies. To develop more efficient regimens for various malignant tumors, the attention has focused on searching for substances to sensiti...